Browsing Háskóli Íslands by Author "Lemarquis, Andri Leo"

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Clinical, cellular and serologic analysis of selective IgA deficiency: Analysis of the Icelandic selective IgA deficiency group

Lemarquis, Andri Leo (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-06-03)

Sértækur IgA skortur (sIgAD) er algengasti galli í sértæka ónæmiskerfinu. Gallinn er skilgreindur sem algjör skortur á IgA með eðlilegum IgG og IgM styrk í sermi. Tíðni sjúkdóma sem tengjast óeðlilegu ónæmissvari er hærri hjá sIgAD ...
Mapping of Signaling Pathways Linked to sIgAD Reveals Impaired IL-21 Driven STAT3 B-Cell Activation

Lemarquis, Andri Leo; Theodors, Fannar; Einarsdottir, Helga K.; Ludviksson, Bjorn (Frontiers Media SA, 2019-03-18)

Objectives: It has recently been shown that individuals with selective IgA deficiency (sIgAD) have defective B cell responses both to T cell dependent and independent mimicking stimulations. The complex intracellular signaling pathways from different ...
Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency

Lemarquis, Andri Leo; Einarsdóttir, Helga K.; Kristjansdóttir, Rakel N.; Jonsdottir, Ingileif; Ludviksson, Bjorn (Frontiers Media SA, 2018-04-27)

Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can ...

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