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Pneumococcal vaccination: Direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Sigurdsson, Samuel
dc.contributor.author Erlendsdóttir, Helga
dc.contributor.author Quirk, Sigríður Júlía
dc.contributor.author Kristjánsson, Júlíus
dc.contributor.author Hauksson, Kristján
dc.contributor.author Andrésdóttir, Birta Dögg Ingudóttir
dc.contributor.author Jónsson, Arnar Jan
dc.contributor.author Halldórsson, Kolbeinn Hans
dc.contributor.author Saemundsson, Arni
dc.contributor.author Ólason, Óli Hilmar
dc.contributor.author Hrafnkelsson, Birgir
dc.contributor.author Kristinsson, Karl G.
dc.contributor.author Haraldsson, Ásgeir
dc.date.accessioned 2018-01-31T16:28:22Z
dc.date.available 2018-01-31T16:28:22Z
dc.date.issued 2017-09
dc.identifier.citation Sigurdsson, S., Erlendsdóttir, H., Quirk, S. J., Kristjánsson, J., Hauksson, K., Andrésdóttir, B. D. I., . . . Haraldsson, Á. (2017). Pneumococcal vaccination: Direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children. Vaccine, 35(39), 5242-5248. doi:https://doi.org/10.1016/j.vaccine.2017.08.020
dc.identifier.issn 0264-410X
dc.identifier.uri https://hdl.handle.net/20.500.11815/554
dc.description.abstract Background Since the introduction of pneumococcal conjugate vaccines, vaccine type pneumococcal carriage and disease has decreased world-wide. The aim was to monitor changes in the nasopharyngeal carriage of pneumococci, the distribution of serotypes and antimicrobial resistance in children before and after initiation of the 10-valent pneumococcal vaccination in 2011, in a previously unvaccinated population. Methods Repeated cross-sectional study at 15 day-care centres in greater Reykjavik area. Nasopharyngeal swabs were collected yearly in March from 2009 to 2015. The swabs were selectively cultured for pneumococci, which were serotyped using latex agglutination and/or PCR and antimicrobial susceptibility determined. Two independent studies were conducted. In study 1, on total impact, isolates from children aged <4 years were included. The vaccine-eligible-cohort (birth-years: 2011–2013, sampled in 2013–2015) was compared with children at the same age born in 2005–2010 and sampled in 2009–2012. In study 2 on herd effect, isolates from older non-vaccine-eligible children (3.5–6.3 years) were compared for the periods before and after the vaccination (2009–2011 vs 2013–2015. Vaccine impact was determined using 1-odds-ratio. Results Following vaccination, the vaccine impact on vaccine type acquisition was 94% (95% CI: 91–96%) in study 1 and 56% (95% CI: 44–65%) in study 2. The impact on serotype 6 A was 33% (95% CI: −9%; 59%) in study 1 and 42% (95% CI: 10–63%) in study 2 with minimal effect on 19A. The non-vaccine serotypes/groups 6C, 11, 15 and 23B were the most common serotypes/groups after vaccination. Isolates from the vaccine-eligible-cohort had lower penicillin MICs, less resistance to erythromycin and co-trimoxazole and less multi resistance than isolates from the control-group. Conclusions The efficacy of the vaccination on vaccine serotypes was high, and a milder effect on vaccine-associated-serotype 6A was observed for the vaccine-eligible-cohort. There was a significant herd effect on vaccine types in older non-vaccine-eligible children. Overall antimicrobial non-susceptibility was reduced.
dc.description.sponsorship Funding for this study was provided by GlaxoSmithKline Biologicals SA and a grant was received from the Landspitali University Hospital Research Fund. GlaxoSmithKline Biologicals SA was provided the opportunity to review a draft version of this manuscript but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript.
dc.format.extent 5242-5248
dc.language.iso en
dc.publisher Elsevier BV
dc.relation.ispartofseries Vaccine;35(39)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Pneumococcal vaccination
dc.subject Day care centre
dc.subject PNSP
dc.subject PCV-10
dc.subject Vaccine impact
dc.subject Herd effect
dc.subject Bólusetningar
dc.subject Háls-, nef- og eyrnasjúkdómar
dc.subject Leikskólabörn
dc.subject Rannsóknir
dc.subject Sýklalyf
dc.title Pneumococcal vaccination: Direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.description.version Peer Reviewed
dc.identifier.journal Vaccine
dc.identifier.doi 10.1016/j.vaccine.2017.08.020
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Raunvísindadeild (HÍ)
dc.contributor.department Faculty of Physical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)
dc.contributor.school School of Engineering and Natural Sciences (UI)

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