dc.contributor.author |
Sabaté San José, Alba |
dc.contributor.author |
Petersen, Petur Henry |
dc.date.accessioned |
2024-09-05T01:07:23Z |
dc.date.available |
2024-09-05T01:07:23Z |
dc.date.issued |
2024 |
dc.identifier.citation |
Sabaté San José , A & Petersen , P H 2024 , ' Absence of meningeal mast cells in the Mitf mutant mouse ' , Frontiers in Cellular Neuroscience , vol. 18 , 1337621 . https://doi.org/10.3389/fncel.2024.1337621 |
dc.identifier.issn |
1662-5102 |
dc.identifier.other |
228316408 |
dc.identifier.other |
c67fe79e-3e9b-4806-85ae-a0bee8f71c14 |
dc.identifier.other |
85185947550 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4975 |
dc.description |
Publisher Copyright: Copyright © 2024 Sabaté San José and Petersen. |
dc.description.abstract |
Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges. |
dc.format.extent |
5763509 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
Frontiers in Cellular Neuroscience; 18() |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
aging |
dc.subject |
inflammation |
dc.subject |
mast cells |
dc.subject |
meninges |
dc.subject |
microphthalmia-associated transcription factor |
dc.subject |
Cellular and Molecular Neuroscience |
dc.title |
Absence of meningeal mast cells in the Mitf mutant mouse |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.3389/fncel.2024.1337621 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85185947550&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |