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| Titill: | Absence of meningeal mast cells in the Mitf mutant mouse |
| Höfundur: |
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| Útgáfa: | 2024 |
| Tungumál: | Enska |
| Umfang: | 5763509 |
| Deild: | Faculty of Medicine |
| Birtist í: | Frontiers in Cellular Neuroscience; 18() |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2024.1337621 |
| Efnisorð: | aging; inflammation; mast cells; meninges; microphthalmia-associated transcription factor; Cellular and Molecular Neuroscience |
| URI: | https://hdl.handle.net/20.500.11815/4975 |
Tilvitnun:Sabaté San José , A & Petersen , P H 2024 , ' Absence of meningeal mast cells in the Mitf mutant mouse ' , Frontiers in Cellular Neuroscience , vol. 18 , 1337621 . https://doi.org/10.3389/fncel.2024.1337621
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Útdráttur:Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.
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Athugasemdir:Publisher Copyright: Copyright © 2024 Sabaté San José and Petersen.
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