Absence of meningeal mast cells in the Mitf mutant mouse

Title:	Absence of meningeal mast cells in the Mitf mutant mouse
Author:	Sabaté San José, Alba Petersen, Petur Henry orcid.org/0000-0001-6622-3002 2 authors Show fewer authors
Date:	2024
Language:	English
Scope:	5763509
Department:	Faculty of Medicine
Series:	Frontiers in Cellular Neuroscience; 18()
ISSN:	1662-5102
DOI:	10.3389/fncel.2024.1337621
Subject:	aging; inflammation; mast cells; meninges; microphthalmia-associated transcription factor; Cellular and Molecular Neuroscience
URI:	https://hdl.handle.net/20.500.11815/4975
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Citation: Sabaté San José , A & Petersen , P H 2024 , ' Absence of meningeal mast cells in the Mitf mutant mouse ' , Frontiers in Cellular Neuroscience , vol. 18 , 1337621 . https://doi.org/10.3389/fncel.2024.1337621
Abstract: Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.
Description: Publisher Copyright: Copyright © 2024 Sabaté San José and Petersen.