dc.contributor.author |
Mathew, A. J. |
dc.contributor.author |
Lund, M. L. |
dc.contributor.author |
Pedersen, M. P. |
dc.contributor.author |
Rasmussen, S. H. |
dc.contributor.author |
Glintborg, B. |
dc.contributor.author |
Loft, A. G. |
dc.contributor.author |
Nissen, M. J. |
dc.contributor.author |
Möller, B. |
dc.contributor.author |
Rodrigues, A. M. |
dc.contributor.author |
Santos, F. P. |
dc.contributor.author |
Rotar, Z. |
dc.contributor.author |
Tomšič, M. |
dc.contributor.author |
Relas, H. |
dc.contributor.author |
Peltomaa, R. |
dc.contributor.author |
Guðbjörnsson, Björn |
dc.contributor.author |
Löve, Þorvarður Jón |
dc.contributor.author |
Kocaer, S. B. |
dc.contributor.author |
Koken Avsar, A. |
dc.contributor.author |
Midtbøll Ørnbjerg, L. |
dc.contributor.author |
Østergaard, M. |
dc.date.accessioned |
2024-06-05T01:04:19Z |
dc.date.available |
2024-06-05T01:04:19Z |
dc.date.issued |
2024 |
dc.identifier.citation |
Mathew , A J , Lund , M L , Pedersen , M P , Rasmussen , S H , Glintborg , B , Loft , A G , Nissen , M J , Möller , B , Rodrigues , A M , Santos , F P , Rotar , Z , Tomšič , M , Relas , H , Peltomaa , R , Guðbjörnsson , B , Löve , Þ J , Kocaer , S B , Koken Avsar , A , Midtbøll Ørnbjerg , L & Østergaard , M 2024 , ' Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors : clinical burden, patient-reported outcomes, and treatment response ' , Scandinavian Journal of Rheumatology , vol. 53 , no. 4 , pp. 237-247 . https://doi.org/10.1080/03009742.2024.2336743 |
dc.identifier.issn |
0300-9742 |
dc.identifier.other |
223195932 |
dc.identifier.other |
86c4d02b-47e8-473a-9b49-24fedcb0baa1 |
dc.identifier.other |
85193698223 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4939 |
dc.description |
Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
dc.description.abstract |
Objective: To explore the registration of enthesitis among biologic-naïve patients with psoriatic arthritis (PsA) initiating tumour necrosis factor inhibitor (TNFi) treatment across 12 European registries, compare the disease burden and patient-reported outcomes (PROs) between patients with and without enthesitis, and assess the enthesitis treatment response. Method: Demographics, clinical characteristics, and PROs at first TNFi (TNFi-1) initiation (baseline) were assessed in patients with PsA, diagnosed by a rheumatologist, with versus without assessment of entheses and between those with versus without enthesitis. Enthesitis scores and resolution frequency were identified at follow-up. Results: Of 10 547 patients in the European Spondyloarthritis (EuroSpA) Research Collaboration Network initiating TNFi, 1357 underwent evaluation for enthesitis. Eight registries included a validated scoring system for enthesitis. At baseline, 874 patients underwent entheses assessment [Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) 485 patients, Spondyloarthritis Research Consortium of Canada (SPARCC) 389 patients]. Enthesitis was detected by MASES in 170/485 (35%, mean score ± sd 3.1 ± 2.4) and by SPARCC in 236/389 (61%, 4 ± 3.4). Achilles enthesitis was most frequent, by both MASES (unilateral/bilateral 28%/9%) and SPARCC (48%/18%). MASES/SPARCC baseline and follow-up scores for TNFi-1 were available for 100/105 patients. Of these, 63 patients (63%) (MASES) and 46 (43.8%) (SPARCC) achieved resolution of enthesitis. The site-specific enthesitis resolution was overall lower at SPARCC sites (peripheral; 63–80%) than at MASES sites (mainly axial; 82–100%) following TNFi-1. Disease activity and PROs were worse in patients with versus without enthesitis. Conclusion: Entheseal assessments are only registered in a minority of patients with PsA in routine care. When assessed, enthesitis was common, and a substantial proportion demonstrated resolution following treatment with TNFi-1. |
dc.format.extent |
11 |
dc.format.extent |
1150748 |
dc.format.extent |
237-247 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Scandinavian Journal of Rheumatology; 53(4) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Gigtarlæknisfræði |
dc.subject |
Rheumatology |
dc.subject |
Immunology and Allergy |
dc.subject |
Immunology |
dc.title |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors : clinical burden, patient-reported outcomes, and treatment response |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1080/03009742.2024.2336743 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85193698223&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Other departments |