dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Dam, Merete |
dc.contributor.author |
Lynggaard, Line Stensig |
dc.contributor.author |
Jónsson, Ólafur Gísli |
dc.contributor.author |
Saulyte Trakymiene, Sonata |
dc.contributor.author |
Palk, Katrin |
dc.contributor.author |
Jarvis, Kirsten |
dc.contributor.author |
Andrés-Jensen, Liv |
dc.contributor.author |
Tuckuviene, Ruta |
dc.contributor.author |
Albertsen, Birgitte Klug |
dc.date.accessioned |
2024-04-25T01:06:09Z |
dc.date.available |
2024-04-25T01:06:09Z |
dc.date.issued |
2024-06 |
dc.identifier.citation |
Dam , M , Lynggaard , L S , Jónsson , Ó G , Saulyte Trakymiene , S , Palk , K , Jarvis , K , Andrés-Jensen , L , Tuckuviene , R & Albertsen , B K 2024 , ' Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol ' , Pediatric Blood and Cancer , vol. 71 , no. 6 , e30937 . https://doi.org/10.1002/pbc.30937 |
dc.identifier.issn |
1545-5009 |
dc.identifier.other |
221850522 |
dc.identifier.other |
db4d4a17-b3d1-405b-9c3a-f892f0983634 |
dc.identifier.other |
85187519052 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4840 |
dc.description |
Publisher Copyright: © 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC. |
dc.description.abstract |
The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form-36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow-up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p =.9). This study underscores the need for comprehensive population-based investigations with validation of PTS instruments in ALL survivors. |
dc.format.extent |
9 |
dc.format.extent |
249965 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
Pediatric Blood and Cancer; 71(6) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Barnalæknisfræði |
dc.subject |
Pediatrics, Perinatology and Child Health |
dc.subject |
Hematology |
dc.subject |
Oncology |
dc.title |
Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1002/pbc.30937 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85187519052&partnerID=8YFLogxK |