Titill: | Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol |
Höfundur: |
|
Útgáfa: | 2024-06 |
Tungumál: | Enska |
Umfang: | 9 |
Háskóli/Stofnun: | Landspitali - The National University Hospital of Iceland |
Birtist í: | Pediatric Blood and Cancer; 71(6) |
ISSN: | 1545-5009 |
DOI: | 10.1002/pbc.30937 |
Efnisorð: | Barnalæknisfræði; Pediatrics, Perinatology and Child Health; Hematology; Oncology |
URI: | https://hdl.handle.net/20.500.11815/4840 |
Tilvitnun:Dam , M , Lynggaard , L S , Jónsson , Ó G , Saulyte Trakymiene , S , Palk , K , Jarvis , K , Andrés-Jensen , L , Tuckuviene , R & Albertsen , B K 2024 , ' Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol ' , Pediatric Blood and Cancer , vol. 71 , no. 6 , e30937 . https://doi.org/10.1002/pbc.30937
|
|
Útdráttur:The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form-36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow-up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p =.9). This study underscores the need for comprehensive population-based investigations with validation of PTS instruments in ALL survivors.
|
|
Athugasemdir:Publisher Copyright: © 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
|