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Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes

Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes


Title: Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
Author: Knutsen, Erik
Das Sajib, Saikat
Fiskaa, Tonje
Lorens, James
Guðjónsson, Þórarinn
Mælandsmo, Gunhild M.
Johansen, Steinar Daae
Seternes, Ole Morten
Perander, Maria
Date: 2023
Language: English
Scope: 90035425
Department: Faculty of Medicine
Other departments
Series: Frontiers in Oncology; 13()
ISSN: 2234-943X
DOI: 10.3389/fonc.2023.1249895
Subject: Náttúrufræðingar; breast cancer; EMT-transcription factors; epithelial-mesenchymal transition; gene expression signature; RNA-Seq; Oncology; Cancer Research
URI: https://hdl.handle.net/20.500.11815/4672

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Citation:

Knutsen , E , Das Sajib , S , Fiskaa , T , Lorens , J , Guðjónsson , Þ , Mælandsmo , G M , Johansen , S D , Seternes , O M & Perander , M 2023 , ' Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes ' , Frontiers in Oncology , vol. 13 , 1249895 . https://doi.org/10.3389/fonc.2023.1249895

Abstract:

Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium is reflected in extensive heterogeneity among breast cancers. Here, we have analyzed RNA-sequencing data from three different mammary epithelial cell line-derived EMT models and identified a robust mammary EMT gene expression signature that separates breast cancers into distinct subgroups. Most strikingly, the basal-like breast cancers form two subgroups displaying partial-EMT and post-EMT gene expression patterns. We present evidence that key EMT-associated transcription factors play distinct roles at different stages of EMT in mammary epithelial cells.

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Publisher Copyright: Copyright © 2023 Knutsen, Das Sajib, Fiskaa, Lorens, Gudjonsson, Mælandsmo, Johansen, Seternes and Perander.

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