dc.contributor.author |
Pérez-Escurza, Oihane |
dc.contributor.author |
Flores-Montero, Juan |
dc.contributor.author |
Óskarsson, Jón Þórir |
dc.contributor.author |
Sanoja-Flores, Luzalba |
dc.contributor.author |
del Pozo, Julio |
dc.contributor.author |
Lecrevisse, Quentin |
dc.contributor.author |
Martín, Silvia |
dc.contributor.author |
Reed, Elín Ruth |
dc.contributor.author |
Hákonardóttir, Guðlaug Katrín |
dc.contributor.author |
Harding, Stephen |
dc.contributor.author |
Þorsteinsdóttir, Sigrún |
dc.contributor.author |
Rögnvaldsson, Sæmundur |
dc.contributor.author |
Löve, Þorvarður Jón |
dc.contributor.author |
Durie, Brian |
dc.contributor.author |
Kristinsson, Sigurður Yngvi |
dc.contributor.author |
Orfao, Alberto |
dc.date.accessioned |
2024-01-24T01:05:22Z |
dc.date.available |
2024-01-24T01:05:22Z |
dc.date.issued |
2023-12-11 |
dc.identifier.citation |
Pérez-Escurza , O , Flores-Montero , J , Óskarsson , J Þ , Sanoja-Flores , L , del Pozo , J , Lecrevisse , Q , Martín , S , Reed , E R , Hákonardóttir , G K , Harding , S , Þorsteinsdóttir , S , Rögnvaldsson , S , Löve , Þ J , Durie , B , Kristinsson , S Y & Orfao , A 2023 , ' Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies : an iSTOPMM study ' , Blood Cancer Journal , vol. 13 , no. 1 , 182 , pp. 182 . https://doi.org/10.1038/s41408-023-00944-1 |
dc.identifier.issn |
2044-5385 |
dc.identifier.other |
214242262 |
dc.identifier.other |
13d012f1-f85f-475b-a99a-99f5e1f191c4 |
dc.identifier.other |
85178176815 |
dc.identifier.other |
38072838 |
dc.identifier.other |
unpaywall: 10.1038/s41408-023-00944-1 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4671 |
dc.description |
Publisher Copyright: © 2023, The Author(s). |
dc.description.abstract |
Monoclonal gammopathy of undetermined significance (MGUS) is the earliest discernible stage of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). Early diagnosis of MG may be compromised by the low-level infiltration, undetectable to low-sensitive methodologies. Here, we investigated the prevalence and immunophenotypic profile of clonal (c) plasma cells (PC) and/or cB-lymphocytes in bone marrow (BM) and blood of subjects with a serum M-component from the iSTOPMM program, using high-sensitive next-generation flow cytometry (NGF), and its utility in the diagnostic classification of early-stage MG. We studied 164 paired BM and blood samples from 82 subjects, focusing the analysis on: 55 MGUS, 12 smoldering MM (SMM) and 8 smoldering WM (SWM). cPC were detected in 84% of the BM samples and cB-lymphocytes in 45%, coexisting in 39% of cases. In 29% of patients, the phenotypic features of cPC and/or cB-lymphocytes allowed a more accurate disease classification, including: 19/55 (35%) MGUS, 1/12 (8%) SMM and 2/8 (25%) SWM. Blood samples were informative in 49% of the BM-positive cases. We demonstrated the utility of NGF for a more accurate diagnostic classification of early-stage MG. |
dc.format.extent |
2138626 |
dc.format.extent |
182 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Blood Cancer Journal; 13(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Gigtarlæknisfræði |
dc.subject |
Blóðlæknisfræði |
dc.subject |
B-Lymphocytes |
dc.subject |
Bone Marrow |
dc.subject |
Humans |
dc.subject |
Monoclonal Gammopathy of Undetermined Significance |
dc.subject |
Multiple Myeloma/diagnosis |
dc.subject |
Paraproteinemias/diagnosis |
dc.subject |
Plasma Cells |
dc.subject |
Smoldering Multiple Myeloma/complications |
dc.subject |
Waldenstrom Macroglobulinemia |
dc.title |
Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies : an iSTOPMM study |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1038/s41408-023-00944-1 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85178176815&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Other departments |