dc.contributor | Landspitali - The National University Hospital of Iceland |
dc.contributor.author | Oltra, Javier |
dc.contributor.author | Habich, Annegret |
dc.contributor.author | Schwarz, Christopher G. |
dc.contributor.author | Nedelska, Zuzana |
dc.contributor.author | Przybelski, Scott A. |
dc.contributor.author | Inguanzo, Anna |
dc.contributor.author | Diaz-Galvan, Patricia |
dc.contributor.author | Lowe, Val J. |
dc.contributor.author | Oppedal, Ketil |
dc.contributor.author | Gonzalez, Maria C. |
dc.contributor.author | Philippi, Nathalie |
dc.contributor.author | Blanc, Frederic |
dc.contributor.author | Barkhof, Frederik |
dc.contributor.author | Lemstra, Afina W. |
dc.contributor.author | Hort, Jakub |
dc.contributor.author | Padovani, Alessandro |
dc.contributor.author | Rektorova, Irena |
dc.contributor.author | Bonanni, Laura |
dc.contributor.author | Massa, Federico |
dc.contributor.author | Kramberger, Milica G. |
dc.contributor.author | Taylor, John Paul |
dc.contributor.author | Snædal, Jón G |
dc.contributor.author | Walker, Zuzana |
dc.contributor.author | Antonini, Angelo |
dc.contributor.author | Dierks, Thomas |
dc.contributor.author | Segura, Barbara |
dc.contributor.author | Junque, Carme |
dc.contributor.author | Westman, Eric |
dc.contributor.author | Boeve, Bradley F. |
dc.contributor.author | Aarsland, Dag |
dc.contributor.author | Kantarci, Kejal |
dc.contributor.author | Ferreira, Daniel |
dc.date.accessioned | 2024-01-16T01:06:26Z |
dc.date.available | 2024-01-16T01:06:26Z |
dc.date.issued | 2023-12-22 |
dc.identifier.citation | Oltra , J , Habich , A , Schwarz , C G , Nedelska , Z , Przybelski , S A , Inguanzo , A , Diaz-Galvan , P , Lowe , V J , Oppedal , K , Gonzalez , M C , Philippi , N , Blanc , F , Barkhof , F , Lemstra , A W , Hort , J , Padovani , A , Rektorova , I , Bonanni , L , Massa , F , Kramberger , M G , Taylor , J P , Snædal , J G , Walker , Z , Antonini , A , Dierks , T , Segura , B , Junque , C , Westman , E , Boeve , B F , Aarsland , D , Kantarci , K & Ferreira , D 2023 , ' Sex differences in brain atrophy in dementia with Lewy bodies ' , Alzheimer's and Dementia . https://doi.org/10.1002/alz.13571 |
dc.identifier.issn | 1552-5260 |
dc.identifier.other | 215570923 |
dc.identifier.other | f1b9d8c0-af77-49d0-8f18-735812037f69 |
dc.identifier.other | 85180259158 |
dc.identifier.uri | https://hdl.handle.net/20.500.11815/4654 |
dc.description | Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. |
dc.description.abstract | INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age. |
dc.format.extent | 1535760 |
dc.format.extent | |
dc.language.iso | en |
dc.relation.ispartofseries | Alzheimer's and Dementia; () |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Öldrunarlæknisfræði |
dc.subject | atrophy |
dc.subject | dementia with Lewy bodies |
dc.subject | magnetic resonance imaging |
dc.subject | sex differences |
dc.subject | Epidemiology |
dc.subject | Health Policy |
dc.subject | Developmental Neuroscience |
dc.subject | Neurology (clinical) |
dc.subject | Geriatrics and Gerontology |
dc.subject | Cellular and Molecular Neuroscience |
dc.subject | Psychiatry and Mental Health |
dc.title | Sex differences in brain atrophy in dementia with Lewy bodies |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version | Peer reviewed |
dc.identifier.doi | 10.1002/alz.13571 |
dc.relation.url | http://www.scopus.com/inward/record.url?scp=85180259158&partnerID=8YFLogxK |