Titill: | Sex differences in brain atrophy in dementia with Lewy bodies |
Höfundur: |
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Útgáfa: | 2023-12-22 |
Tungumál: | Enska |
Umfang: | 1535760 |
Háskóli/Stofnun: | Landspitali - The National University Hospital of Iceland |
Birtist í: | Alzheimer's and Dementia; () |
ISSN: | 1552-5260 |
DOI: | 10.1002/alz.13571 |
Efnisorð: | Öldrunarlæknisfræði; atrophy; dementia with Lewy bodies; magnetic resonance imaging; sex differences; Epidemiology; Health Policy; Developmental Neuroscience; Neurology (clinical); Geriatrics and Gerontology; Cellular and Molecular Neuroscience; Psychiatry and Mental Health |
URI: | https://hdl.handle.net/20.500.11815/4654 |
Tilvitnun:Oltra , J , Habich , A , Schwarz , C G , Nedelska , Z , Przybelski , S A , Inguanzo , A , Diaz-Galvan , P , Lowe , V J , Oppedal , K , Gonzalez , M C , Philippi , N , Blanc , F , Barkhof , F , Lemstra , A W , Hort , J , Padovani , A , Rektorova , I , Bonanni , L , Massa , F , Kramberger , M G , Taylor , J P , Snædal , J G , Walker , Z , Antonini , A , Dierks , T , Segura , B , Junque , C , Westman , E , Boeve , B F , Aarsland , D , Kantarci , K & Ferreira , D 2023 , ' Sex differences in brain atrophy in dementia with Lewy bodies ' , Alzheimer's and Dementia . https://doi.org/10.1002/alz.13571
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Útdráttur:INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.
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Athugasemdir:Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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