dc.contributor.author |
Gyawali, Sanjay |
dc.contributor.author |
López-Cervantes, Juan Pablo |
dc.contributor.author |
Jõgi, Nils Oskar |
dc.contributor.author |
Mustafa, Tehmina |
dc.contributor.author |
Johannessen, Ane |
dc.contributor.author |
Janson, Christer |
dc.contributor.author |
Holm, Mathias |
dc.contributor.author |
Modig, Lars |
dc.contributor.author |
Cramer, Christine |
dc.contributor.author |
Gíslason, Þórarinn |
dc.contributor.author |
Svanes, Cecilie |
dc.contributor.author |
Shigdel, Rajesh |
dc.date.accessioned |
2023-06-13T01:03:29Z |
dc.date.available |
2023-06-13T01:03:29Z |
dc.date.issued |
2023-05-22 |
dc.identifier.citation |
Gyawali , S , López-Cervantes , J P , Jõgi , N O , Mustafa , T , Johannessen , A , Janson , C , Holm , M , Modig , L , Cramer , C , Gíslason , Þ , Svanes , C & Shigdel , R 2023 , ' Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study ' , ERJ Open Research , vol. 9 , no. 3 , 00011-2023 . https://doi.org/10.1183/23120541.00011-2023 |
dc.identifier.issn |
2312-0541 |
dc.identifier.other |
147552118 |
dc.identifier.other |
70310ba9-8eeb-49d1-bf2a-f1a7d726b2e9 |
dc.identifier.other |
37228275 |
dc.identifier.other |
PubMedCentral: PMC10204863 |
dc.identifier.other |
85160605318 |
dc.identifier.other |
unpaywall: 10.1183/23120541.00011-2023 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4252 |
dc.description |
Publisher Copyright: © 2023, European Respiratory Society. All rights reserved. |
dc.description.abstract |
BACKGROUND: Tuberculosis (TB) infection induces profound local and systemic, immunological and inflammatory changes that could influence the development of other respiratory diseases; however, the association between TB and asthma is only partly understood. Our objective was to study the association of TB with asthma and respiratory symptoms in a Nordic-Baltic population-based study. METHODS: We included data from the Respiratory Health in Northern Europe (RHINE) study, in which information on general characteristics, TB infection, asthma and asthma-like symptoms were collected using standardised postal questionnaires. Asthma was defined based on asthma medication usage and/or asthma attacks 12 months prior to the study, and/or by a report of ≥three out of five respiratory symptoms in the last 12 months. Allergic/nonallergic asthma were defined as asthma with/without nasal allergy. The associations of TB with asthma outcomes were analysed using logistic regressions with adjustments for age, sex, smoking, body mass index and parental education. RESULTS: We included 8379 study participants aged 50-75 years, 61 of whom reported having had TB. In adjusted analyses, participants with a history of TB had higher odds of asthma (OR 1.99, 95% CI 1.13-3.47). The associations were consistent for nonallergic asthma (OR 2.17, 95% CI 1.16-4.07), but not for allergic asthma (OR 1.20, 95% CI 0.53-2.71). CONCLUSION: We found that in a large Northern European population-based cohort, persons with a history of TB infection more frequently had asthma and asthma symptoms. We speculate that this may reflect long-term effects of TB, including direct damage to the airways and lungs, as well as inflammatory responses. |
dc.format.extent |
632444 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
ERJ Open Research; 9(3) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Lungnalæknisfræði |
dc.subject |
Pulmonary and Respiratory Medicine |
dc.title |
Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1183/23120541.00011-2023 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85160605318&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Internal Medicine and Emergency Services |