Titill: | Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study |
Höfundur: |
... 2 fleiri höfundar Sýna alla höfunda |
Útgáfa: | 2023-05-22 |
Tungumál: | Enska |
Umfang: | 632444 |
Deild: | Faculty of Medicine Internal Medicine and Emergency Services |
Birtist í: | ERJ Open Research; 9(3) |
ISSN: | 2312-0541 |
DOI: | 10.1183/23120541.00011-2023 |
Efnisorð: | Lungnalæknisfræði; Pulmonary and Respiratory Medicine |
URI: | https://hdl.handle.net/20.500.11815/4252 |
Tilvitnun:Gyawali , S , López-Cervantes , J P , Jõgi , N O , Mustafa , T , Johannessen , A , Janson , C , Holm , M , Modig , L , Cramer , C , Gíslason , Þ , Svanes , C & Shigdel , R 2023 , ' Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study ' , ERJ Open Research , vol. 9 , no. 3 , 00011-2023 . https://doi.org/10.1183/23120541.00011-2023
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Útdráttur:BACKGROUND: Tuberculosis (TB) infection induces profound local and systemic, immunological and inflammatory changes that could influence the development of other respiratory diseases; however, the association between TB and asthma is only partly understood. Our objective was to study the association of TB with asthma and respiratory symptoms in a Nordic-Baltic population-based study. METHODS: We included data from the Respiratory Health in Northern Europe (RHINE) study, in which information on general characteristics, TB infection, asthma and asthma-like symptoms were collected using standardised postal questionnaires. Asthma was defined based on asthma medication usage and/or asthma attacks 12 months prior to the study, and/or by a report of ≥three out of five respiratory symptoms in the last 12 months. Allergic/nonallergic asthma were defined as asthma with/without nasal allergy. The associations of TB with asthma outcomes were analysed using logistic regressions with adjustments for age, sex, smoking, body mass index and parental education. RESULTS: We included 8379 study participants aged 50-75 years, 61 of whom reported having had TB. In adjusted analyses, participants with a history of TB had higher odds of asthma (OR 1.99, 95% CI 1.13-3.47). The associations were consistent for nonallergic asthma (OR 2.17, 95% CI 1.16-4.07), but not for allergic asthma (OR 1.20, 95% CI 0.53-2.71). CONCLUSION: We found that in a large Northern European population-based cohort, persons with a history of TB infection more frequently had asthma and asthma symptoms. We speculate that this may reflect long-term effects of TB, including direct damage to the airways and lungs, as well as inflammatory responses.
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Athugasemdir:Publisher Copyright: © 2023, European Respiratory Society. All rights reserved.
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