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Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

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dc.contributor.author Di, Xiaxia
dc.contributor.author Harðardóttir, Ingibjörg
dc.contributor.author Freysdóttir, Jóna
dc.contributor.author Wang, Dongdong
dc.contributor.author Gustafson, Kirk R
dc.contributor.author Ómarsdóttir, Sesselja Sigurborg
dc.contributor.author Molinski, Tadeusz F
dc.date.accessioned 2023-04-22T01:05:05Z
dc.date.available 2023-04-22T01:05:05Z
dc.date.issued 2023-04
dc.identifier.citation Di , X , Harðardóttir , I , Freysdóttir , J , Wang , D , Gustafson , K R , Ómarsdóttir , S S & Molinski , T F 2023 , ' Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti ' , Molecules , vol. 28 , no. 7 , 2937 . https://doi.org/10.3390/molecules28072937
dc.identifier.issn 1420-3049
dc.identifier.other 122052833
dc.identifier.other 9d36d9fc-e082-4514-a9e3-617c38a76941
dc.identifier.other 37049700
dc.identifier.other PubMedCentral: PMC10095911
dc.identifier.other 85152332899
dc.identifier.other unpaywall: 10.3390/molecules28072937
dc.identifier.uri https://hdl.handle.net/20.500.11815/4152
dc.description Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors.
dc.description.abstract Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.
dc.format.extent 1045055
dc.format.extent
dc.language.iso en
dc.relation.ispartofseries Molecules; 28(7)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Náttúrufræðingar
dc.subject Animals
dc.subject Humans
dc.subject Geodia/chemistry
dc.subject Alkaloids/pharmacology
dc.subject Cytokines
dc.subject Anti-Inflammatory Agents
dc.subject Molecular Structure
dc.subject dendritic cells
dc.subject Geodia barretti
dc.subject herbipoline
dc.subject 6-bromoindole
dc.subject anti-inflammatory activity
dc.subject Drug Discovery
dc.subject Analytical Chemistry
dc.subject Chemistry (miscellaneous)
dc.subject Molecular Medicine
dc.subject Physical and Theoretical Chemistry
dc.subject Pharmaceutical Science
dc.subject Organic Chemistry
dc.title Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.3390/molecules28072937
dc.relation.url http://www.scopus.com/inward/record.url?scp=85152332899&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Clinical Laboratory Services, Diagnostics and Blood Bank
dc.contributor.department Other departments
dc.contributor.department Faculty of Pharmaceutical Sciences


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