Opin vísindi

Decreased postural control in adult survivors of childhood cancer treated with chemotherapy

Decreased postural control in adult survivors of childhood cancer treated with chemotherapy


Titill: Decreased postural control in adult survivors of childhood cancer treated with chemotherapy
Höfundur: Einarsson, Einar Jón
Patel, Mitesh
Petersen, Hannes   orcid.org/0000-0002-2327-523X
Wiebe, Thomas
Fransson, Per-Anders
Magnusson, Måns
Moëll, Christian
Útgáfa: 2016-11-10
Tungumál: Enska
Umfang: 36784
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: School of Health Sciences (UI)
Heilbrigðisvísindasvið (HÍ)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Scientific Reports;6(1)
ISSN: 2045-2322
DOI: 10.1038/srep36784
Efnisorð: Chemotherapy; Motor control; Regeneration; Nervous system; Sensorimotor processing; Lyfjameðferð; Krabbamein; Hreyfistjórn; Taugakerfi
URI: https://hdl.handle.net/20.500.11815/392

Skoða fulla færslu

Tilvitnun:

Einarsson, E.-J., Patel, M., Petersen, H., Wiebe, T., Fransson, P.-A., Magnusson, M., & Moëll, C. (2016). Decreased postural control in adult survivors of childhood cancer treated with chemotherapy. 6, 36784. doi:10.1038/srep36784

Útdráttur:

The objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.

Leyfi:

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Skrár

Þetta verk birtist í eftirfarandi safni/söfnum:


Fletta

Um vefinn

Reikningurinn minn