Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Lahti, Jari; Tuominen, Samuli; Yang, Qiong; Pergola, Giulio; Ahmad, Shahzad; Amin, Najaf; Armstrong, Nicola J.; Beiser, Alexa; Bey, Katharina; Bis, Joshua C.; Boerwinkle, Eric; Bressler, Jan; Campbell, Archie; Campbell, Harry; Chen, Qiang; Corley, Janie; Cox, Simon R.; Davies, Gail; De Jager, Philip L.; Derks, Eske M.; Faul, Jessica D.; Fitzpatrick, Annette L.; Fohner, Alison E.; Ford, Ian; Fornage, Myriam; Gerring, Zachary; Grabe, Hans J.; Grodstein, Francine; Gudnason, Vilmundur; Simonsick, Eleanor; Holliday, Elizabeth G.; Joshi, Peter K.; Kajantie, Eero; Kaprio, Jaakko; Karell, Pauliina; Kleineidam, Luca; Knol, Maria J.; Kochan, Nicole A.; Kwok, John B.; Leber, Markus; Lam, Max; Lee, Teresa; Li, Shuo; Loukola, Anu; Luck, Tobias; Marioni, Riccardo E.; Mather, Karen A.; Medland, Sarah; Mirza, Saira S.; Nalls, Mike A.

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Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Title:	Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Author:	Lahti, Jari Tuominen, Samuli Yang, Qiong Pergola, Giulio Ahmad, Shahzad Amin, Najaf Armstrong, Nicola J. Beiser, Alexa Bey, Katharina Bis, Joshua C. ... 40 more authors Show all authors Boerwinkle, Eric Bressler, Jan Campbell, Archie Campbell, Harry Chen, Qiang Corley, Janie Cox, Simon R. Davies, Gail De Jager, Philip L. Derks, Eske M. Faul, Jessica D. Fitzpatrick, Annette L. Fohner, Alison E. Ford, Ian Fornage, Myriam Gerring, Zachary Grabe, Hans J. Grodstein, Francine Gudnason, Vilmundur orcid.org/0000-0001-5696-0084 Simonsick, Eleanor Holliday, Elizabeth G. Joshi, Peter K. Kajantie, Eero Kaprio, Jaakko Karell, Pauliina Kleineidam, Luca Knol, Maria J. Kochan, Nicole A. Kwok, John B. Leber, Markus Lam, Max Lee, Teresa Li, Shuo Loukola, Anu Luck, Tobias Marioni, Riccardo E. Mather, Karen A. Medland, Sarah Mirza, Saira S. Nalls, Mike A. 50 authors Show fewer authors
Date:	2022-08-16
Language:	English
Scope:	13
Department:	Faculty of Medicine
Series:	Molecular Psychiatry; 27(11)
ISSN:	1359-4184
DOI:	10.1038/s41380-022-01710-8
Subject:	Memory, Short-Term/physiology; Learning; Verbal Learning; Multifactorial Inheritance; Brain; Psychiatry and Mental Health; Cellular and Molecular Neuroscience; Molecular Biology
URI:	https://hdl.handle.net/20.500.11815/3865
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Citation: Lahti , J , Tuominen , S , Yang , Q , Pergola , G , Ahmad , S , Amin , N , Armstrong , N J , Beiser , A , Bey , K , Bis , J C , Boerwinkle , E , Bressler , J , Campbell , A , Campbell , H , Chen , Q , Corley , J , Cox , S R , Davies , G , De Jager , P L , Derks , E M , Faul , J D , Fitzpatrick , A L , Fohner , A E , Ford , I , Fornage , M , Gerring , Z , Grabe , H J , Grodstein , F , Gudnason , V , Simonsick , E , Holliday , E G , Joshi , P K , Kajantie , E , Kaprio , J , Karell , P , Kleineidam , L , Knol , M J , Kochan , N A , Kwok , J B , Leber , M , Lam , M , Lee , T , Li , S , Loukola , A , Luck , T , Marioni , R E , Mather , K A , Medland , S , Mirza , S S & Nalls , M A 2022 , ' Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning ' , Molecular Psychiatry , vol. 27 , no. 11 , pp. 4419-4431 . https://doi.org/10.1038/s41380-022-01710-8
Abstract: Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Description: Publisher Copyright: © 2022, The Author(s).