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Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe : an ERA Registry study

Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe : an ERA Registry study


Title: Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe : an ERA Registry study
Author: Huijben, Jilske A
Kramer, Anneke
Kerschbaum, Julia
de Meester, Johan
Collart, Frederic
Arévalo, Olga Lucía Rodríguez
Helve, Jaakko
Lassalle, Mathilde
Pálsson, Runólfur
Ten Dam, Marc
... 11 more authors Show all authors
Date: 2022-08-17
Language: English
Scope:
Department: Other departments
Faculty of Medicine
Series: Nephrology, dialysis, transplantation; ()
ISSN: 0931-0509
DOI: https://doi.org/10.1093/ndt/gfac165
Subject: Nýrnalæknisfræði
URI: https://hdl.handle.net/20.500.11815/3852

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Citation:

Huijben , J A , Kramer , A , Kerschbaum , J , de Meester , J , Collart , F , Arévalo , O L R , Helve , J , Lassalle , M , Pálsson , R , Ten Dam , M , Casula , A , Methven , S , Ortiz , A , Ferraro , P M , Segelmark , M , Mingo , P U , Arici , M , Reisæter , A V , Stendahl , M , Stel , V S & Jager , K J 2022 , ' Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe : an ERA Registry study ' , Nephrology, dialysis, transplantation . https://doi.org/10.1093/ndt/gfac165

Abstract:

INTRODUCTION: The aim of this study was to describe the trends in the incidence, prevalence and survival of patients on kidney replacement therapy (KRT) for end-stage kidney disease (ESKD) across Europe from 2008 to 2017. METHODS: Data from renal registries in 9 countries and 16 regions that provided individual patient data to the ERA Registry from 2008 to 2017 were included. These registries cover 34% of the general population in Europe. Crude and standardized incidence and prevalence per million population (pmp) were determined. Trends over time were studied using Joinpoint regression. Survival probabilities were estimated using Kaplan-Meier analysis and hazard ratios (HRs) using Cox regression analysis. RESULTS: The standardized incidence of KRT was stable (annual percentage change [APC]: -1.48 [-3.15; 0.21]) from 2008 (146.0 pmp) to 2011 (141.6 pmp), followed by a slight increase (APC: 1.01 [0.43; 1.60]) to 148.0 pmp in 2017, although trends in incidence varied across countries. This increase was primarily due to a rise in the incidence of KRT in men older than 65 years. Moreover, as a cause of kidney failure, diabetes mellitus is increasing. The standardized prevalence increased from 2008 (990.0 pmp) to 2017 (1166.8 pmp) (APC: 1.82 [1.75; 1.89]). Patient survival on KRT improved in the time period 2011-2013 compared with 2008-2010 (adjusted HR: 0.94 [0.93; 0.95). CONCLUSION: This study showed an overall increase in the incidence and prevalence of KRT for ESKD as well as an increase in the KRT patient survival over the last decade in Europe.

Description:

© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.

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