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Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data


Titill: Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data
Höfundur: Rejnmark, Lars
Bislev, Lise Sofie
Cashman, Kevin D.
Eiríksdóttir, Guðný
Gaksch, Martin
Grübler, Martin
Grimnes, Guri
Gudnason, Vilmundur   orcid.org/0000-0001-5696-0084
Lips, Paul
Pilz, Stefan
... 3 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-07-07
Tungumál: Enska
Umfang: e0180512
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: PLoS ONE;12(7)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0180512
Efnisorð: Vitamin D; Observational studies; Birth weight; Blood pressure; Depression; Obesity; D vítamín; Vítamín; Rannsóknir; Blóðþrýstingur; Offita
URI: https://hdl.handle.net/20.500.11815/364

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Tilvitnun:

Rejnmark L, Bislev LS, Cashman KD, Eiríksdottir G, Gaksch M, Grübler M, et al. (2017) Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE 12(7): e0180512. https://doi.org/10.1371/journal.pone.0180512

Útdráttur:

Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation. Methods and findings We identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes. For each outcome, we summarized the results from available SRs and scrutinized included RCTs for a number of predefined characteristics. We identified 54 SRs including data from 210 RCTs. Most MAs as well as the individual RCTs reported null-findings on risk of cardiovascular diseases, type 2 diabetes, weight-loss, and malignant diseases. Beneficial effects of vitamin D supplementation was reported in 1 of 4 MAs on depression, 2 of 9 MAs on blood pressure, 3 of 7 MAs on respiratory tract infections, and 8 of 12 MAs on mortality. Most RCTs have primarily been performed to determine skeletal outcomes, whereas non-skeletal effects have been assessed as secondary outcomes. Only one-third of the RCTs had low level of 25OHD as a criterion for inclusion and a mean baseline 25OHD level below 50 nmol/L was only present in less than half of the analyses. Conclusions Published RCTs have mostly been performed in populations without low 25OHD levels. The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels.

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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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