dc.contributor.author | Qin, Hua |
dc.contributor.author | Keenan, Brendan T. |
dc.contributor.author | Mazzotti, Diego R. |
dc.contributor.author | Vaquerizo-Villar, Fernando |
dc.contributor.author | Kraemer, Jan F |
dc.contributor.author | Wessel, Niels |
dc.contributor.author | Tufik, Sergio |
dc.contributor.author | Bittencourt, Lia |
dc.contributor.author | Cistulli, Peter A. |
dc.contributor.author | de Chazal, Philip |
dc.contributor.author | Sutherland, Kate |
dc.contributor.author | Singh, Bhajan |
dc.contributor.author | Pack, Allan I. |
dc.contributor.author | Chen, Ning Hung |
dc.contributor.author | Fietze, Ingo |
dc.contributor.author | Gíslason, Þórarinn |
dc.contributor.author | Holfinger, Steven |
dc.contributor.author | Magalang, Ulysses J. |
dc.contributor.author | Penzel, Thomas |
dc.date.accessioned | 2022-11-15T01:04:10Z |
dc.date.available | 2022-11-15T01:04:10Z |
dc.date.issued | 2021-05 |
dc.identifier.citation | Qin , H , Keenan , B T , Mazzotti , D R , Vaquerizo-Villar , F , Kraemer , J F , Wessel , N , Tufik , S , Bittencourt , L , Cistulli , P A , de Chazal , P , Sutherland , K , Singh , B , Pack , A I , Chen , N H , Fietze , I , Gíslason , Þ , Holfinger , S , Magalang , U J & Penzel , T 2021 , ' Heart rate variability during wakefulness as a marker of obstructive sleep apnea severity ' , Sleep , vol. 44 , no. 5 . https://doi.org/10.1093/sleep/zsab018 |
dc.identifier.issn | 0161-8105 |
dc.identifier.other | 49000874 |
dc.identifier.other | 01c0f733-b0dd-4f5d-9373-e3ed8f3d7d86 |
dc.identifier.other | researchoutputwizard: hdl.handle.net/2336/621870 |
dc.identifier.other | 33506267 |
dc.identifier.other | 85106539408 |
dc.identifier.uri | https://hdl.handle.net/20.500.11815/3607 |
dc.description.abstract | Study objectives: Patients with obstructive sleep apnea (OSA) exhibit heterogeneous heart rate variability (HRV) during wakefulness and sleep. We investigated the influence of OSA severity on HRV parameters during wakefulness in a large international clinical sample. Methods: 1247 subjects (426 without OSA and 821 patients with OSA) were enrolled from the Sleep Apnea Global Interdisciplinary Consortium. HRV parameters were calculated during a 5-minute wakefulness period with spontaneous breathing prior to the sleep study, using time-domain, frequency-domain and nonlinear methods. Differences in HRV were evaluated among groups using analysis of covariance, controlling for relevant covariates. Results: Patients with OSA showed significantly lower time-domain variations and less complexity of heartbeats compared to individuals without OSA. Those with severe OSA had remarkably reduced HRV compared to all other groups. Compared to non-OSA patients, those with severe OSA had lower HRV based on SDNN (adjusted mean: 37.4 vs. 46.2 ms; p < 0.0001), RMSSD (21.5 vs. 27.9 ms; p < 0.0001), ShanEn (1.83 vs. 2.01; p < 0.0001), and Forbword (36.7 vs. 33.0; p = 0.0001). While no differences were found in frequency-domain measures overall, among obese patients there was a shift to sympathetic dominance in severe OSA, with a higher LF/HF ratio compared to obese non-OSA patients (4.2 vs. 2.7; p = 0.009). Conclusions: Time-domain and nonlinear HRV measures during wakefulness are associated with OSA severity, with severe patients having remarkably reduced and less complex HRV. Frequency-domain measures show a shift to sympathetic dominance only in obese OSA patients. Thus, HRV during wakefulness could provide additional information about cardiovascular physiology in OSA patients. Clinical trial information: A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities (German Clinical Trials Register - DKRS, DRKS00003966) https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00003966. Keywords: autonomic nervous activity; frequency domain analysis; heart rate variability; nonlinear dynamic analysis; obstructive sleep apnea; time domain analysis; wakefulness. |
dc.format.extent | 2864408 |
dc.format.extent | |
dc.language.iso | en |
dc.relation.ispartofseries | Sleep; 44(5) |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Lungnalæknisfræði |
dc.subject | autonomic nervous activity |
dc.subject | frequency domain analysis |
dc.subject | heart rate variability |
dc.subject | nonlinear dynamic analysis |
dc.subject | obstructive sleep apnea |
dc.subject | time domain analysis |
dc.subject | wakefulness |
dc.subject | Kæfisvefn |
dc.subject | Hjartsláttarmælingar |
dc.subject | Heart Rate |
dc.subject | Sleep Apnea, Obstructive |
dc.subject | autonomic nervous activity |
dc.subject | frequency domain analysis |
dc.subject | heart rate variability |
dc.subject | nonlinear dynamic analysis |
dc.subject | obstructive sleep apnea |
dc.subject | time domain analysis |
dc.subject | wakefulness |
dc.subject | Kæfisvefn |
dc.subject | Hjartsláttarmælingar |
dc.subject | Heart Rate |
dc.subject | Sleep Apnea, Obstructive |
dc.title | Heart rate variability during wakefulness as a marker of obstructive sleep apnea severity |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version | Peer reviewed |
dc.identifier.doi | 10.1093/sleep/zsab018 |
dc.relation.url | https://academic.oup.com/sleep/article-abstract/44/5/zsab018/6121869?redirectedFrom=fulltext |
dc.contributor.department | Faculty of Medicine |