Opin vísindi

Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia : a nationwide follow-up study

Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia : a nationwide follow-up study


Titill: Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia : a nationwide follow-up study
Höfundur: Axelsson, Gísli Þór
Halldorsson, Arnljotur Bjorn
Jónsson, Helgi
Eyþórsson, Elías Sæbjörn
Sigurðardóttir, Erla Sigríður
Harðardóttir, Hrönn
Guðmundsson, Gunnar
Hansdóttir, Sif
Útgáfa: 2022-10-01
Tungumál: Enska
Umfang: 921020
Háskóli/Stofnun: Landspitali - The National University Hospital of Iceland
Deild: Interdisciplinary Graduate Studies
Faculty of Medicine
Birtist í: BMJ Open Respiratory Research; 9(1)
ISSN: 2052-4439
DOI: 10.1136/bmjresp-2022-001347
Efnisorð: Gigtarlæknisfræði; Lungnalæknisfræði; COVID-19; Imaging/CT MRI etc; Respiratory Measurement; Acute Disease; Follow-Up Studies; Humans; Survivors; Tomography, X-Ray Computed; Pulmonary and Respiratory Medicine
URI: https://hdl.handle.net/20.500.11815/3529

Skoða fulla færslu

Tilvitnun:

Axelsson , G Þ , Halldorsson , A B , Jónsson , H , Eyþórsson , E S , Sigurðardóttir , E S , Harðardóttir , H , Guðmundsson , G & Hansdóttir , S 2022 , ' Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia : a nationwide follow-up study ' , BMJ Open Respiratory Research , vol. 9 , no. 1 , 001347 . https://doi.org/10.1136/bmjresp-2022-001347

Útdráttur:

INTRODUCTION: Considering the pulmonary burden caused by acute COVID-19, questions remain of respiratory consequences after recovery. The aim of the study was to describe respiratory function of COVID-19 pneumonia survivors at mid-term follow-up (median 68 days) and assess whether impairments were predicted by acute illness severity or residual CT abnormalities. METHODS: Residents of Iceland that had COVID-19 and oxygen saturation ≤94% from 28 February 2020 to 30 April 2021 were offered a clinical follow-up visit with an interview, a 6 min walk test (6MWT), spirometry with gas exchange measurement and chest CT. The results of these examinations were described, grouped by the level of care during acute illness. The associations of disease severity and CT abnormalities at follow-up with subjective dyspnoea, 6MWT results and lung function test results were estimated with regression analyses. RESULTS: Of 190 eligible patients, 164 (86%) participated in the study. Of those, 32 had never been admitted to hospital, 103 were admitted to hospital without intensive care and 29 had required intensive care. At a follow-up, need for intensive care during acute illness was associated with shorter walking distance on 6MWT, lower oxygen saturation and lower DLCO. Imaging abnormalities at follow-up were observed for most participants (74%) and the magnitude of these changes was associated with decrements in 6MWT distance, oxygen saturation, forced vital capacity and DLCO. CONCLUSIONS: The findings show that impaired exercise capacity and lung physiology at follow-up were primarily observed for patients with COVID-19 pneumonia that required intensive care treatment and/or had persistent imaging abnormalities.

Athugasemdir:

Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Funding Information: GTA is funded by the Eimskip University Fund. GG is funded by the Landspitali Scientific Fund A-2020-018, A-2020-017 and A-2021-018 as well as the University of Iceland Research Fund 2022. Publisher Copyright: © © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Skrár

Þetta verk birtist í eftirfarandi safni/söfnum: