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Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Haugen, Ida K.
dc.contributor.author Felson, David T.
dc.contributor.author Abhishek, Abhishek
dc.contributor.author Berenbaum, Francis
dc.contributor.author Bierma-Zeinstra, Sita
dc.contributor.author Borgen, Tove
dc.contributor.author Herrero Beaumont, Gabriel
dc.contributor.author Ishimori, Mariko
dc.contributor.author Jonsson, Helgi
dc.contributor.author Kroon, Féline P.B.
dc.contributor.author Maheu, Emmanuel
dc.contributor.author Ramonda, Roberta
dc.contributor.author Ritschl, Valentin
dc.contributor.author Stamm, Tanja A.
dc.contributor.author Van Der Heijde, Desirée
dc.contributor.author Wittoek, Ruth
dc.contributor.author Greibrokk, Elsie
dc.contributor.author Smeets, Wilma
dc.contributor.author Kloppenburg, Margreet
dc.date.accessioned 2022-08-31T01:03:14Z
dc.date.available 2022-08-31T01:03:14Z
dc.date.issued 2020-06-25
dc.identifier.citation Haugen , I K , Felson , D T , Abhishek , A , Berenbaum , F , Bierma-Zeinstra , S , Borgen , T , Herrero Beaumont , G , Ishimori , M , Jonsson , H , Kroon , F P B , Maheu , E , Ramonda , R , Ritschl , V , Stamm , T A , Van Der Heijde , D , Wittoek , R , Greibrokk , E , Smeets , W & Kloppenburg , M 2020 , ' Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis ' , RMD Open , vol. 6 , no. 2 , e001265 . https://doi.org/10.1136/rmdopen-2020-001265
dc.identifier.issn 2056-5933
dc.identifier.other PURE: 43305926
dc.identifier.other PURE UUID: 1ffe134c-ce57-4ea8-a501-1e6e4c103e5c
dc.identifier.other Scopus: 85087098516
dc.identifier.uri https://hdl.handle.net/20.500.11815/3393
dc.description The project on the development of new classification criteria for hand OA is funded by EULAR. The EULAR executive committee has not been involved in the study design, analyses or interpretation of results. Publisher Copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstract Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Discrimination between groups was assessed by calculating the area under receiver operating curves (AUC). Results Strong associations with hand OA were observed for radiographic osteophytes (OR = 1.62, 95 CI 1.40 to 1.88) and joint space narrowing (JSN) (OR = 1.57, 95 CI 1.36 to 1.82) in the distal interphalangeal (DIP) joints with excellent discrimination (AUC = 0.82 for both). For osteophytes and JSN, we found acceptable discrimination between groups in the proximal interphalangeal joints (AUC = 0.77 and 0.78, respectively), but poorer discrimination in the first carpometacarpal joints (AUC = 0.67 and 0.63, respectively). Painful DIP joints were associated with hand OA, but were less able to discriminate between groups (AUC = 0.67). Age and family history of OA were positively associated with hand OA, whereas negative associations were found for pain, stiffness and soft tissue swelling in metacarpophalangeal joints, pain and marginal erosions in wrists, longer morning stiffness, inflammatory biomarkers and autoantibodies. Conclusions Differences in symptoms, clinical findings, radiographic changes and laboratory tests were found in patients with hand OA versus controls. Radiographic OA features, especially in DIP joints, were best suited to discriminate between groups.
dc.language.iso en
dc.relation.ispartofseries RMD Open; 6(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Ankylosing Spondylitis
dc.subject Anti-TNF
dc.subject Chondrocalcinosis
dc.subject Chondrocytes
dc.subject Epidemiology
dc.subject Gene Polymorphism
dc.subject Hand Osteoarthritis
dc.subject Knee Osteoarthritis
dc.subject MRI
dc.subject Osteoarthritis
dc.subject Outcomes research
dc.subject Patient perspective
dc.subject Qualitative research
dc.subject Rehabilitation
dc.subject Spondyloarthritis
dc.subject Ultrasonography
dc.subject Immunology and Allergy
dc.subject Rheumatology
dc.subject Immunology
dc.title Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 32584781
dc.identifier.doi https://doi.org/10.1136/rmdopen-2020-001265
dc.relation.url http://www.scopus.com/inward/record.url?scp=85087098516&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Internal Medicine and Emergency Services

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