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Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis

Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis


Title: Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis
Author: Haugen, Ida K.
Felson, David T.
Abhishek, Abhishek
Berenbaum, Francis
Bierma-Zeinstra, Sita
Borgen, Tove
Herrero Beaumont, Gabriel
Ishimori, Mariko
Jonsson, Helgi   orcid.org/0000-0003-0187-8985
Kroon, Féline P.B.
... 9 more authors Show all authors
Date: 2020-06-25
Language: English
Scope:
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Internal Medicine and Emergency Services
Series: RMD Open; 6(2)
ISSN: 2056-5933
DOI: https://doi.org/10.1136/rmdopen-2020-001265
Subject: Ankylosing Spondylitis; Anti-TNF; Chondrocalcinosis; Chondrocytes; Epidemiology; Gene Polymorphism; Hand Osteoarthritis; Knee Osteoarthritis; MRI; Osteoarthritis; Outcomes research; Patient perspective; Qualitative research; Rehabilitation; Spondyloarthritis; Ultrasonography; Immunology and Allergy; Rheumatology; Immunology
URI: https://hdl.handle.net/20.500.11815/3393

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Citation:

Haugen , I K , Felson , D T , Abhishek , A , Berenbaum , F , Bierma-Zeinstra , S , Borgen , T , Herrero Beaumont , G , Ishimori , M , Jonsson , H , Kroon , F P B , Maheu , E , Ramonda , R , Ritschl , V , Stamm , T A , Van Der Heijde , D , Wittoek , R , Greibrokk , E , Smeets , W & Kloppenburg , M 2020 , ' Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis ' , RMD Open , vol. 6 , no. 2 , e001265 . https://doi.org/10.1136/rmdopen-2020-001265

Abstract:

Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Discrimination between groups was assessed by calculating the area under receiver operating curves (AUC). Results Strong associations with hand OA were observed for radiographic osteophytes (OR = 1.62, 95 CI 1.40 to 1.88) and joint space narrowing (JSN) (OR = 1.57, 95 CI 1.36 to 1.82) in the distal interphalangeal (DIP) joints with excellent discrimination (AUC = 0.82 for both). For osteophytes and JSN, we found acceptable discrimination between groups in the proximal interphalangeal joints (AUC = 0.77 and 0.78, respectively), but poorer discrimination in the first carpometacarpal joints (AUC = 0.67 and 0.63, respectively). Painful DIP joints were associated with hand OA, but were less able to discriminate between groups (AUC = 0.67). Age and family history of OA were positively associated with hand OA, whereas negative associations were found for pain, stiffness and soft tissue swelling in metacarpophalangeal joints, pain and marginal erosions in wrists, longer morning stiffness, inflammatory biomarkers and autoantibodies. Conclusions Differences in symptoms, clinical findings, radiographic changes and laboratory tests were found in patients with hand OA versus controls. Radiographic OA features, especially in DIP joints, were best suited to discriminate between groups.

Description:

The project on the development of new classification criteria for hand OA is funded by EULAR. The EULAR executive committee has not been involved in the study design, analyses or interpretation of results. Publisher Copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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