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Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension

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dc.contributor.author Jóhannesson, Gauti
dc.contributor.author Qvarlander, Sara
dc.contributor.author Wåhlin, Anders
dc.contributor.author Ambarki, Khalid
dc.contributor.author Hallberg, Per
dc.contributor.author Eklund, Anders
dc.contributor.author Lindén, Christina
dc.date.accessioned 2022-08-26T01:04:05Z
dc.date.available 2022-08-26T01:04:05Z
dc.date.issued 2020-10
dc.identifier.citation Jóhannesson , G , Qvarlander , S , Wåhlin , A , Ambarki , K , Hallberg , P , Eklund , A & Lindén , C 2020 , ' Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension ' , Investigative Ophthalmology and Visual Science , vol. 61 , no. 12 , 17 . https://doi.org/10.1167/IOVS.61.12.17
dc.identifier.issn 0146-0404
dc.identifier.other PURE: 42894101
dc.identifier.other PURE UUID: 3b8ead46-7e3e-4052-a697-225d5a2594a1
dc.identifier.other Scopus: 85093986781
dc.identifier.uri https://hdl.handle.net/20.500.11815/3370
dc.description Financial support was provided through regional agreements between Umea University and Vasterbotten County Council and also by grants from Knut and Alice Wallenberg Foundation, Crown Princess Margareta's Foundation, Ogonfonden, Insamlingsstiftelserna vid Umea universitet, the Swedish Medical Society Foundation, the Cronqvist Foundation, the Regnér Foundation and Swedish Society for Medical Research. The funding organizations had no role in the design or conduct of this research. The authors alone are responsible for the content and writing of the paper. Publisher Copyright: © 2020 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.
dc.description.abstract PURPOSE. To investigate if decrease of IOP affects the volumetric blood flow rate in the ophthalmic artery (OA) in patients with previously untreated ocular hypertension. METHODS. Subjects with untreated ocular hypertension (n = 30; mean age 67 ± 8 years; 14 females) underwent ophthalmologic examination and a 3-Tesla magnetic resonance imaging investigation. The magnetic resonance imaging included three-dimensional high-resolution phase-contrast magnetic resonance imaging to measure the OA blood flow rate. The subjects received latanoprost once daily in the eye with higher pressure, the untreated eye served as control. The same measurements were repeated approximately 1 week later. RESULTS. The mean OA blood flow rate before and after treatment was 12.4 ± 4.4 and 12.4 ± 4.6 mL/min in the treated eye (mean ± SD; P = 0.92) and 13.5 ± 5.2 and 13.4 ± 4.1 mL/min in the control eye (P = 0.92). There was no significant difference between the treated and control eye regarding blood flow rate before (P = 0.13) or after treatment (P = 0.18), or change in blood flow rate after treatment (0.1 ± 3.1 vs. −0.1 ± 4.0 mL/min, P = 0.84). Latanoprost decreased the IOP by 7.2 ± 3.1 mm Hg in the treated eye (P < 0.01). CONCLUSIONS. The results indicate that a significant lowering of IOP does not affect the blood flow rate of the OA in ocular hypertension subjects. The ability to maintain blood supply to the eye independent of the IOP could be a protective mechanism in preserving vision in subjects with ocular hypertension.
dc.language.iso en
dc.relation.ispartofseries Investigative Ophthalmology and Visual Science; 61(12)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Blood flow
dc.subject Intraocular pressure
dc.subject Magnetic resonance imaging
dc.subject Ophthalmic artery
dc.subject Augnsjúkdómar
dc.subject Ophthalmology
dc.subject Sensory Systems
dc.subject Cellular and Molecular Neuroscience
dc.title Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33074299
dc.identifier.doi https://doi.org/10.1167/IOVS.61.12.17
dc.relation.url http://www.scopus.com/inward/record.url?scp=85093986781&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine

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