Opin vísindi

Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension

Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension


Title: Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension
Author: Jóhannesson, Gauti
Qvarlander, Sara
Wåhlin, Anders
Ambarki, Khalid
Hallberg, Per
Eklund, Anders
Lindén, Christina
Date: 2020-10
Language: English
Scope:
Department: Faculty of Medicine
Series: Investigative Ophthalmology and Visual Science; 61(12)
ISSN: 0146-0404
DOI: https://doi.org/10.1167/IOVS.61.12.17
Subject: Blood flow; Intraocular pressure; Magnetic resonance imaging; Ophthalmic artery; Augnsjúkdómar; Ophthalmology; Sensory Systems; Cellular and Molecular Neuroscience
URI: https://hdl.handle.net/20.500.11815/3370

Show full item record

Citation:

Jóhannesson , G , Qvarlander , S , Wåhlin , A , Ambarki , K , Hallberg , P , Eklund , A & Lindén , C 2020 , ' Intraocular pressure decrease does not affect blood flow rate of ophthalmic artery in ocular hypertension ' , Investigative Ophthalmology and Visual Science , vol. 61 , no. 12 , 17 . https://doi.org/10.1167/IOVS.61.12.17

Abstract:

PURPOSE. To investigate if decrease of IOP affects the volumetric blood flow rate in the ophthalmic artery (OA) in patients with previously untreated ocular hypertension. METHODS. Subjects with untreated ocular hypertension (n = 30; mean age 67 ± 8 years; 14 females) underwent ophthalmologic examination and a 3-Tesla magnetic resonance imaging investigation. The magnetic resonance imaging included three-dimensional high-resolution phase-contrast magnetic resonance imaging to measure the OA blood flow rate. The subjects received latanoprost once daily in the eye with higher pressure, the untreated eye served as control. The same measurements were repeated approximately 1 week later. RESULTS. The mean OA blood flow rate before and after treatment was 12.4 ± 4.4 and 12.4 ± 4.6 mL/min in the treated eye (mean ± SD; P = 0.92) and 13.5 ± 5.2 and 13.4 ± 4.1 mL/min in the control eye (P = 0.92). There was no significant difference between the treated and control eye regarding blood flow rate before (P = 0.13) or after treatment (P = 0.18), or change in blood flow rate after treatment (0.1 ± 3.1 vs. −0.1 ± 4.0 mL/min, P = 0.84). Latanoprost decreased the IOP by 7.2 ± 3.1 mm Hg in the treated eye (P < 0.01). CONCLUSIONS. The results indicate that a significant lowering of IOP does not affect the blood flow rate of the OA in ocular hypertension subjects. The ability to maintain blood supply to the eye independent of the IOP could be a protective mechanism in preserving vision in subjects with ocular hypertension.

Description:

Financial support was provided through regional agreements between Umea University and Vasterbotten County Council and also by grants from Knut and Alice Wallenberg Foundation, Crown Princess Margareta's Foundation, Ogonfonden, Insamlingsstiftelserna vid Umea universitet, the Swedish Medical Society Foundation, the Cronqvist Foundation, the Regnér Foundation and Swedish Society for Medical Research. The funding organizations had no role in the design or conduct of this research. The authors alone are responsible for the content and writing of the paper. Publisher Copyright: © 2020 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.

Files in this item

This item appears in the following Collection(s)