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Estrogen-related mechanisms in sex differences of hypertension and target organ damage

Estrogen-related mechanisms in sex differences of hypertension and target organ damage


Title: Estrogen-related mechanisms in sex differences of hypertension and target organ damage
Author: Sabbatini, Andrea Rodrigues
Kararigas, Georgios
Date: 2020-06-01
Language: English
Scope:
Department: Faculty of Medicine
Series: Biology of Sex Differences; 11(1)
ISSN: 2042-6410
DOI: https://doi.org/10.1186/s13293-020-00306-7
Subject: Blood pressure; Cardiovascular; Heart; Sex hormone; Vasculature; Blóðþrýstingur; Gender Studies; Endocrinology
URI: https://hdl.handle.net/20.500.11815/3348

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Citation:

Sabbatini , A R & Kararigas , G 2020 , ' Estrogen-related mechanisms in sex differences of hypertension and target organ damage ' , Biology of Sex Differences , vol. 11 , no. 1 , 31 . https://doi.org/10.1186/s13293-020-00306-7

Abstract:

Hypertension (HTN) is a primary risk factor for cardiovascular (CV) events, target organ damage (TOD), premature death and disability worldwide. The pathophysiology of HTN is complex and influenced by many factors including biological sex. Studies show that the prevalence of HTN is higher among adults aged 60 and over, highlighting the increase of HTN after menopause in women. Estrogen (E2) plays an important role in the development of systemic HTN and TOD, exerting several modulatory effects. The influence of E2 leads to alterations in mechanisms regulating the sympathetic nervous system, renin-angiotensin-aldosterone system, body mass, oxidative stress, endothelial function and salt sensitivity; all associated with a crucial inflammatory state and influenced by genetic factors, ultimately resulting in cardiac, vascular and renal damage in HTN. In the present article, we discuss the role of E2 in mechanisms accounting for the development of HTN and TOD in a sex-specific manner. The identification of targets with therapeutic potential would contribute to the development of more efficient treatments according to individual needs.

Description:

GK acknowledges support from the DZHK (German Centre for Cardiovascular Research) and the BMBF (German Ministry for Education and Research). Publisher Copyright: © 2020 The Author(s).

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