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Estrogen-related mechanisms in sex differences of hypertension and target organ damage

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dc.contributor.author Sabbatini, Andrea Rodrigues
dc.contributor.author Kararigas, Georgios
dc.date.accessioned 2022-08-25T01:02:36Z
dc.date.available 2022-08-25T01:02:36Z
dc.date.issued 2020-06-01
dc.identifier.citation Sabbatini , A R & Kararigas , G 2020 , ' Estrogen-related mechanisms in sex differences of hypertension and target organ damage ' , Biology of Sex Differences , vol. 11 , no. 1 , 31 . https://doi.org/10.1186/s13293-020-00306-7
dc.identifier.issn 2042-6410
dc.identifier.other PURE: 43313324
dc.identifier.other PURE UUID: 71fa8b70-45b5-4d77-b9dd-6578eaca3bc3
dc.identifier.other Scopus: 85085909407
dc.identifier.uri https://hdl.handle.net/20.500.11815/3348
dc.description GK acknowledges support from the DZHK (German Centre for Cardiovascular Research) and the BMBF (German Ministry for Education and Research). Publisher Copyright: © 2020 The Author(s).
dc.description.abstract Hypertension (HTN) is a primary risk factor for cardiovascular (CV) events, target organ damage (TOD), premature death and disability worldwide. The pathophysiology of HTN is complex and influenced by many factors including biological sex. Studies show that the prevalence of HTN is higher among adults aged 60 and over, highlighting the increase of HTN after menopause in women. Estrogen (E2) plays an important role in the development of systemic HTN and TOD, exerting several modulatory effects. The influence of E2 leads to alterations in mechanisms regulating the sympathetic nervous system, renin-angiotensin-aldosterone system, body mass, oxidative stress, endothelial function and salt sensitivity; all associated with a crucial inflammatory state and influenced by genetic factors, ultimately resulting in cardiac, vascular and renal damage in HTN. In the present article, we discuss the role of E2 in mechanisms accounting for the development of HTN and TOD in a sex-specific manner. The identification of targets with therapeutic potential would contribute to the development of more efficient treatments according to individual needs.
dc.format.extent
dc.language.iso en
dc.relation.ispartofseries Biology of Sex Differences; 11(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Blood pressure
dc.subject Cardiovascular
dc.subject Heart
dc.subject Sex hormone
dc.subject Vasculature
dc.subject Blóðþrýstingur
dc.subject Gender Studies
dc.subject Endocrinology
dc.title Estrogen-related mechanisms in sex differences of hypertension and target organ damage
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview
dc.description.version Peer reviewed
dc.identifier.pmid 32487164
dc.identifier.doi https://doi.org/10.1186/s13293-020-00306-7
dc.relation.url http://www.scopus.com/inward/record.url?scp=85085909407&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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