Opin vísindi

Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Sigurbergsdóttir, Aðalbjörg Ýr
dc.contributor.author Love, Thorvardur Jon
dc.contributor.author Kristinsson, Sigurður Yngvi
dc.date.accessioned 2022-08-20T01:03:27Z
dc.date.available 2022-08-20T01:03:27Z
dc.date.issued 2022-04-28
dc.identifier.citation Sigurbergsdóttir , A Ý , Love , T J & Kristinsson , S Y 2022 , ' Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance ' , Frontiers in Immunology , vol. 13 , 876271 , pp. 876271 . https://doi.org/10.3389/fimmu.2022.876271
dc.identifier.issn 1664-3224
dc.identifier.other PURE: 56885967
dc.identifier.other PURE UUID: 1fff7a48-4968-451d-8843-780581d7bf0b
dc.identifier.other Scopus: 85130007031
dc.identifier.other unpaywall: 10.3389/fimmu.2022.876271
dc.identifier.uri https://hdl.handle.net/20.500.11815/3329
dc.description Copyright © 2022 Sigurbergsdóttir, Love and Kristinsson.
dc.description.abstract Various epidemiological studies, including case reports and -series in addition to larger, population-based studies, have reported an increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma in individuals with a prior history of immune-related conditions. This is believed to support the role of chronic antigen stimulation in the pathogenesis of these conditions. In this short review, we summarize some of the largest population-based studies researching autoimmune diseases, infections, and the subsequent risk of MGUS, and discuss our understanding on its etiology and pathogenesis. Furthermore, we highlight important methodological limitations of previous studies in the field, but almost all studies on MGUS have been based on clinical, possibly biased, cohorts. Finally, we discuss future directions in researching the associations of MGUS and other disorders, including immune-related conditions, where screening studies play an important role.
dc.format.extent 876271
dc.language.iso en
dc.relation.ispartofseries Frontiers in Immunology; 13()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Blóðlæknisfræði
dc.subject Vísindadeild
dc.subject autoimmune diseases
dc.subject chronic antigen stimulation
dc.subject infections
dc.subject iStopMM study
dc.subject monoclonal gammopathy of undetermined significance
dc.subject risk
dc.subject Autoimmunity
dc.subject Monoclonal Gammopathy of Undetermined Significance/epidemiology
dc.subject Humans
dc.subject Immune System Diseases/complications
dc.subject Autoimmune Diseases
dc.subject Paraproteinemias
dc.subject Multiple Myeloma
dc.subject Immunology and Allergy
dc.subject Immunology
dc.title Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35572590
dc.identifier.doi https://doi.org/10.3389/fimmu.2022.876271
dc.relation.url http://www.scopus.com/inward/record.url?scp=85130007031&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Other departments
dc.contributor.department Cancer Center


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