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Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance

Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance


Title: Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance
Author: Sigurbergsdóttir, Aðalbjörg Ýr
Love, Thorvardur Jon
Kristinsson, Sigurður Yngvi
Date: 2022-04-28
Language: English
Scope:
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Other departments
Cancer Center
Series: Frontiers in Immunology; 13()
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2022.876271
Subject: Vísindadeild; Blóðlæknisfræði; autoimmune diseases; chronic antigen stimulation; infections; iStopMM study; monoclonal gammopathy of undetermined significance; risk; Immunology and Allergy; Immunology
URI: https://hdl.handle.net/20.500.11815/3329

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Citation:

Sigurbergsdóttir , A Ý , Love , T J & Kristinsson , S Y 2022 , ' Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance ' , Frontiers in Immunology , vol. 13 , 876271 . https://doi.org/10.3389/fimmu.2022.876271

Abstract:

Various epidemiological studies, including case reports and -series in addition to larger, population-based studies, have reported an increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma in individuals with a prior history of immune-related conditions. This is believed to support the role of chronic antigen stimulation in the pathogenesis of these conditions. In this short review, we summarize some of the largest population-based studies researching autoimmune diseases, infections, and the subsequent risk of MGUS, and discuss our understanding on its etiology and pathogenesis. Furthermore, we highlight important methodological limitations of previous studies in the field, but almost all studies on MGUS have been based on clinical, possibly biased, cohorts. Finally, we discuss future directions in researching the associations of MGUS and other disorders, including immune-related conditions, where screening studies play an important role.

Description:

Publisher Copyright: Copyright © 2022 Sigurbergsdóttir, Love and Kristinsson.

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