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Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Møllehave, Line Tang
dc.contributor.author Eliasen, Marie Holm
dc.contributor.author Strēle, Ieva
dc.contributor.author Linneberg, Allan
dc.contributor.author Moreno-Reyes, Rodrigo
dc.contributor.author Ivanova, Ludmila B.
dc.contributor.author Kusić, Zvonko
dc.contributor.author Erlund, Iris
dc.contributor.author Ittermann, Till
dc.contributor.author Nagy, Endre V.
dc.contributor.author Gunnarsdottir, Ingibjorg
dc.contributor.author Arbelle, Jonathan Eli
dc.contributor.author Troen, Aaron Milton
dc.contributor.author Pīrāgs, Valdis
dc.contributor.author Dahl, Lisbeth
dc.contributor.author Hubalewska-Dydejczyk, Alicja
dc.contributor.author Trofimiuk-Müldner, Malgorzata
dc.contributor.author de Castro, João Jacome
dc.contributor.author Marcelino, Mafalda
dc.contributor.author Gaberšček, Simona
dc.contributor.author Zaltel, Katja
dc.contributor.author Puig-Domingo, Manuel
dc.contributor.author Vila, Lluis
dc.contributor.author Manousou, Sofia
dc.contributor.author Nyström, Helena Filipsson
dc.contributor.author Zimmermann, Michael Bruce
dc.contributor.author Mullan, Karen R.
dc.contributor.author Woodside, Jayne Valerie
dc.contributor.author Völzke, Henry
dc.contributor.author Thuesen, Betina Heinsbæk
dc.date.accessioned 2022-08-18T01:03:02Z
dc.date.available 2022-08-18T01:03:02Z
dc.date.issued 2022-03-10
dc.identifier.citation Møllehave , L T , Eliasen , M H , Strēle , I , Linneberg , A , Moreno-Reyes , R , Ivanova , L B , Kusić , Z , Erlund , I , Ittermann , T , Nagy , E V , Gunnarsdottir , I , Arbelle , J E , Troen , A M , Pīrāgs , V , Dahl , L , Hubalewska-Dydejczyk , A , Trofimiuk-Müldner , M , de Castro , J J , Marcelino , M , Gaberšček , S , Zaltel , K , Puig-Domingo , M , Vila , L , Manousou , S , Nyström , H F , Zimmermann , M B , Mullan , K R , Woodside , J V , Völzke , H & Thuesen , B H 2022 , ' Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration ' , Endocrine Connections , vol. 11 , no. 3 , e210525 . https://doi.org/10.1530/EC-21-0525
dc.identifier.issn 2049-3614
dc.identifier.other PURE: 56716394
dc.identifier.other PURE UUID: 1d796bc5-f70a-4e4f-a62a-33da7b863daf
dc.identifier.other Scopus: 85127550080
dc.identifier.uri https://hdl.handle.net/20.500.11815/3326
dc.description Funding Information: The EUthyroid project was an ambitious collaborative project with participation and representatives from most EU countries funded by the European Union’s Horizon 2020 research and innovation program under grant agreement no. 634453. The overall aim of the EUthyroid project was to ‘evaluate iodine deficiency prevention and monitoring programs in European countries, to initiate capacity building for harmonized European ID prevention and monitoring programs’. Funding Information: This work was supported by the European Union?s Horizon 2020 research and innovation program under grant agreement no. 634453. Data analyses were further supported by the project SUPERTHYREOSE, funded by the German G-BA (VSF2_2019-167). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 The authors Published by Bioscientifica Ltd.
dc.description.abstract Objective: Registers of diagnoses and treatments exist in different forms in the European countries and are potential sources to answer important research questions. Prevalence and incidence of thyroid diseases are highly dependent on iodine intake and, thus, iodine deficiency disease prevention programs. We aimed to collect European register data on thyroid outcomes to compare the rates between countries/regions with different iodine status and prevention programs. Design: Register-based cross-sectional study. Methods: National register data on thyroid diagnoses and treatments were requested from 23 European countries/regions. The provided data were critically assessed for suitability for comparison between countries/regions. Sex-and age-standardized rates were calculated. Results: Register data on ≥1 thyroid diagnoses or treatments were available from 22 countries/regions. After critical assessment, data on medication, surgery, and cancer were found suitable for comparison between 9, 10, and 13 countries/regions, respectively. Higher rates of antithyroid medication and thyroid surgery for benign disease and lower rates of thyroid hormone therapy were found for countries with iodine insufficiency before approx. 2001, and no relationship was observed with recent iodine intake or prevention programs. Conclusions: The collation of register data on thyroid outcomes from European countries is impeded by a high degree of heterogeneity in the availability and quality of data between countries. Nevertheless, a relationship between historic iodine intake and rates of treatments for hyper-and hypothyroid disorders is indicated. This study illustrates both the challenges and the potential for the application of register data of thyroid outcomes across Europe.
dc.language.iso en
dc.relation.ispartofseries Endocrine Connections; 11(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Næringarfræðingar
dc.subject Skjaldkirtilssjúkdómar
dc.subject Joð
dc.subject Europe
dc.subject iodine
dc.subject registries
dc.subject thyroid diseases
dc.subject Internal Medicine
dc.subject Endocrinology, Diabetes and Metabolism
dc.subject Endocrinology
dc.title Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35044931
dc.identifier.doi https://doi.org/10.1530/EC-21-0525
dc.relation.url http://www.scopus.com/inward/record.url?scp=85127550080&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition
dc.contributor.department Other departments

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