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Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration

Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration


Title: Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration
Author: Møllehave, Line Tang
Eliasen, Marie Holm
Strēle, Ieva
Linneberg, Allan
Moreno-Reyes, Rodrigo
Ivanova, Ludmila B.
Kusić, Zvonko
Erlund, Iris
Ittermann, Till
Nagy, Endre V.
... 20 more authors Show all authors
Date: 2022-03
Language: English
Scope:
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Food Science and Nutrition
Other departments
Series: Endocrine Connections; 11(3)
ISSN: 2049-3614
DOI: https://doi.org/10.1530/EC-21-0525
Subject: Næringarfræðingar; Skjaldkirtilssjúkdómar; Joð; Europe; iodine; registries; thyroid diseases; Internal Medicine; Endocrinology, Diabetes and Metabolism; Endocrinology
URI: https://hdl.handle.net/20.500.11815/3326

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Citation:

Møllehave , L T , Eliasen , M H , Strēle , I , Linneberg , A , Moreno-Reyes , R , Ivanova , L B , Kusić , Z , Erlund , I , Ittermann , T , Nagy , E V , Gunnarsdottir , I , Arbelle , J E , Troen , A M , Pīrāgs , V , Dahl , L , Hubalewska-Dydejczyk , A , Trofimiuk-Müldner , M , de Castro , J J , Marcelino , M , Gaberšček , S , Zaltel , K , Puig-Domingo , M , Vila , L , Manousou , S , Nyström , H F , Zimmermann , M B , Mullan , K R , Woodside , J V , Völzke , H & Thuesen , B H 2022 , ' Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration ' , Endocrine Connections , vol. 11 , no. 3 , e210525 . https://doi.org/10.1530/EC-21-0525

Abstract:

Objective: Registers of diagnoses and treatments exist in different forms in the European countries and are potential sources to answer important research questions. Prevalence and incidence of thyroid diseases are highly dependent on iodine intake and, thus, iodine deficiency disease prevention programs. We aimed to collect European register data on thyroid outcomes to compare the rates between countries/regions with different iodine status and prevention programs. Design: Register-based cross-sectional study. Methods: National register data on thyroid diagnoses and treatments were requested from 23 European countries/regions. The provided data were critically assessed for suitability for comparison between countries/regions. Sex-and age-standardized rates were calculated. Results: Register data on ≥1 thyroid diagnoses or treatments were available from 22 countries/regions. After critical assessment, data on medication, surgery, and cancer were found suitable for comparison between 9, 10, and 13 countries/regions, respectively. Higher rates of antithyroid medication and thyroid surgery for benign disease and lower rates of thyroid hormone therapy were found for countries with iodine insufficiency before approx. 2001, and no relationship was observed with recent iodine intake or prevention programs. Conclusions: The collation of register data on thyroid outcomes from European countries is impeded by a high degree of heterogeneity in the availability and quality of data between countries. Nevertheless, a relationship between historic iodine intake and rates of treatments for hyper-and hypothyroid disorders is indicated. This study illustrates both the challenges and the potential for the application of register data of thyroid outcomes across Europe.

Description:

Funding Information: The EUthyroid project was an ambitious collaborative project with participation and representatives from most EU countries funded by the European Union’s Horizon 2020 research and innovation program under grant agreement no. 634453. The overall aim of the EUthyroid project was to ‘evaluate iodine deficiency prevention and monitoring programs in European countries, to initiate capacity building for harmonized European ID prevention and monitoring programs’. Funding Information: This work was supported by the European Union?s Horizon 2020 research and innovation program under grant agreement no. 634453. Data analyses were further supported by the project SUPERTHYREOSE, funded by the German G-BA (VSF2_2019-167). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 The authors Published by Bioscientifica Ltd.

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