Opin vísindi

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries


Title: National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries
Author: Taddei, Cristina
Jackson, Rod
Zhou, Bin
Bixby, Honor
Danaei, Goodarz
Di Cesare, Mariachiara
Kuulasmaa, Kari
Hajifathalian, Kaveh
Bentham, James
Bennett, James E.
... 351 more authors Show all authors
Date: 2020-02-01
Language: English
Scope: 20
Department: Faculty of Medicine
Series: International Journal of Epidemiology; 49(1)
ISSN: 0300-5771
DOI: https://doi.org/10.1093/ije/dyz099
Subject: Blóðfita; Kólesteról; Blood lipids; HDL cholesterol; LDL cholesterol; Multi-country study; Total cholesterol; Epidemiology
URI: https://hdl.handle.net/20.500.11815/3303

Show full item record

Citation:

Taddei , C , Jackson , R , Zhou , B , Bixby , H , Danaei , G , Di Cesare , M , Kuulasmaa , K , Hajifathalian , K , Bentham , J , Bennett , J E , Aekplakorn , W , Cifkova , R , Dallongeville , J , Debacquer , D , Giampaoli , S , Guðnason , V G , Khang , Y H , Laatikainen , T , Mann , J , Marques-Vidal , P , Mensah , G , Müller-Nurasyid , M , Ninomiya , T , Petkeviciene , J , Rodríguez-Artalejo , F , Servais , J , Söderberg , S , Stavreski , B , Wilsgaard , T , Zdrojewski , T , Zhao , D , Stevens , G A , Savin , S , Cowan , M J , Riley , L M , Ezzati , M , Adams , R J , Ahrens , W , Amouyel , P , Amuzu , A , Anderssen , S A , Ariansen , I , Arveiler , D , Aspelund , T , Auvinen , J , Avdicová , M , Banach , M , Bandosz , P , Banegas , J R , Barbagallo , C M , Bata , I , Baur , L A , Beaglehole , R , Bernotiene , G , Bi , Y , Bienek , A , Björkelund , C , Bo , S , Boehm , B O , Bonaccio , M , Bongard , V , Borchini , R , Borghs , H , Breckenkamp , J , Brenner , H , Bruno , G , Busch , M , Cabreradeleón , A , Capuano , V , Casanueva , F F , Casas , J P , Caserta , C A , Censi , L , Chen , F , Chen , S , Chirlaque , M D , Cho , B , Cho , Y , Chudek , J , Claessens , F , Clarke , J , Clays , E , Cooper , C , Costanzo , S , Cottel , D , Cowell , C , Crujeiras , A B , Cui , L , D'Arrigo , G , Dauchet , L , De Backer , G , De Bacquer , D , De Gaetano , G , De Henauw , S , De Smedt , D , Dennison , E , Deschamps , V , Dicastelnuovo , A , Dobson , A J , Donfrancesco , C , Döring , A , Drygas , W , Du , Y , Dziankowska-Zaborszczyk , E , Eggertsen , R , Ekelund , U , Elosua , R , Eriksson , J G , Evans , A , Faeh , D , Felix-Redondo , F J , Fernández-Bergés , D , Ferrari , M , Ferrieres , J , Finn , J D , Forslund , A S , Forsner , M , Frontera , G , Fujita , Y , Gaciong , Z , Galvano , F , Gao , J , Garcia-De-La-Hera , M , Garnett , S , Gaspoz , J M , Gasull , M , Gates , L , Gianfagna , F , Gill , T K , Giovannelli , J , Goltzman , D , Gonzalezgross , M , Gottrand , F , Graff-Iversen , S , Grafnetter , D , Gregor , R D , Grodzicki , T , Grosso , G , Gruden , G , Gu , D , Guallar-Castillón , P , Gudmundsson , E F , Guessous , I , Gunnlaugsdottir , J , Gutzwiller , F , Hardy , R , Hata , J , Haugsgjerd , T , Hayes , A J , He , J , He , Y , Herrala , S , Tapanihihtaniemi , I , Hobbs , M , Hopman , W M , Maríahuerta , J , Huybrechts , I , Iacoviello , L , Iannone , A G , Ikeda , N , Iwasaki , M , Jamrozik , K , Janszky , I , Jarvelin , M R , Jasienska , G , Jennings , G , Jeong , S L , Qiangjiang , C , Joffres , M , Jokelainen , J J , Jonas , J B , Jóźwiak , J , Kajantie , E O , Kauhanen , J , Keil , U , Keinänen-Kiukaanniemi , S , Kersting , M , Kiechl-Kohlendorfer , U , Kiechl , S , Kim , J , Kim , Y Y , Klumbiene , J , Knoflach , M , Ko , S , Kolle , E , Korpelainen , R , Koskinen , S , Kouda , K , Kratzer , W , Kriemler , S , Krokstad , S , Kujala , U , Kurjata , P , Hinglam , T , Lanska , V , Lappas , G , Laugsand , L E , Lee , J , Lehtimäki , T , Li , Y , Lilly , C L , Lin , X , Lind , L , Lissner , L , Liu , J , Lopez-Garcia , E , Lorbeer , R , Eugeniolozano , J , Luksiene , D , Lundqvist , A , Lundqvist , R , Lytsy , P , Ma , G , Machi , S , Maggi , S , Magliano , D J , Mann , J I , Manzato , E , Mathiesen , E B , McLachlan , S , McLean , R M , Scott , B S , Meirhaeghe , A , Christa , C , Metcalf , P , Mi , J , Miller , J C , Moreno , L , Morin , S , Mossakowska , M , Muiesan , M L , Mursu , J , Nakamura , H , Námešná , J , Matthias , M , Marianavarrete-Muñoz , E , Neal , W A , Nenko , I , Niiranen , T J , Ning , G , Noale , M , Norie , S , Noto , D , O'Neill , T , O'Reilly , D , Oh , K , Olafsson , Ö , Michelpaccaud , F , Pajak , A , Palmieri , L , Panza , F , Parnell , W R , Peltonen , M , Peters , A , Petersmann , A , Pigeot , I , Pilotto , L , Piwonska , A , Plans-Rubió , P , Porta , M , Price , J F , Puder , J J , Puhakka , S , Radisauskas , R , Raitakari , O , Ramos , R , Redon , J , Rigo , F , Rodriguez-Perez , M C , Romaguera , D , Ronkainen , K , Rosengren , A , Roy , J G R , Ruidavets , J B , Rutkowski , M , Salanave , B , Salmerón , D , Salomaa , V , Salonen , J T , Salvetti , M , Sans , S , Saramies , J L , Saum , K U , Scheidt-Nave , C , Schienkiewitz , A , Schipf , S , Schmidt , C , Schöttker , B , Sebert , S , Sen , A , Shaw , J E , Shibuya , K , Wookshin , D , Shiri , R , Simons , J , Simons , L A , Sjöström , M , Slowikowska-Hilczer , J , Slusarczyk , P , Solfrizzi , V , Sonestedt , E , Soumare , A , Staessen , J A , Stathopoulou , M G , Steene-Johannessen , J , Stehle , P , Stieber , J , Stöckl , D , Stokwiszewski , J , Sundström , J , Suriyawongpaisal , P , Tamosiunas , A , Jootan , E , Taylor , A , Tell , G , Thijs , L , Tolonen , H K , Topór-Madry , R , Josétormo , M , Torrent , M , Tsugane , S , Tuomainen , T P , Tuomilehto , J , Tzourio , C , Uusitalo , H M T , Vanherck , K , Vanderschueren , D , Vanuzzo , D , Vatten , L , Vega , T , Veronesi , G , Vioque , J , Virtanen , J , Visvikis-Siest , S , Vollenweider , P , Voutilainen , S , Vrijheid , M , Wagner , A , Wagner , A , Wang , M D , Wang , Q , Xingwang , Y , Wannamethee , S G , Wei , W , Wiecek , A , Willeit , J , Willeit , P , Wojtyniak , B , Wong , A , Woodward , M , Giwercmanwu , A , Wu , F C , Wu , S , Xu , H , Xu , L , Yan , W , Yang , X , Ye , X , Yoshihara , A , Zambon , S & Zhao , W 2020 , ' National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries ' , International Journal of Epidemiology , vol. 49 , no. 1 , pp. 173-192 . https://doi.org/10.1093/ije/dyz099

Abstract:

Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.

Description:

This work was supported by the Wellcome Trust (grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z). R.C. acknowledges funding from the Ministry of Health of the Czech Republic (grant number 15-27109A). Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association.

Files in this item

This item appears in the following Collection(s)