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Funding Information: This study was funded by The Swedish Cancer Society (CF2016/795 and 2018/765) and Nyckelfonden, Örebro, Sweden (2015). The funders had no role in the design and conduct of the study, collection, analysis, and interpretation of the data, and writing and approval of the manuscript. Funding Information: This study was funded by The Swedish Cancer Society (CF2016/795 and 2018/765) and Nyckelfonden, ?rebro, Sweden (2015). The funders had no role in the design and conduct of the study, collection, analysis, and interpretation of the data, and writing and approval of the manuscript. This randomized clinical trial was approved by the ethics committee at ?rebro University Hospital and was registered at the ISRCTN registry www.isrctn.com (No. ISRCTN45953686). Written informed consent was obtained from all individual participants included in the study. All authors accept the publication of this work and all patients provided signed inform consent to use their data. The datasets generated and/or analyzed during the current study are not publicly available to protect participant confidentiality but can be partly provided from authors on reasonable request. The authors declare that they have no competing interest. This study was funded by The Swedish Cancer Society (CF2016/795 and 2018/765) and Nyckelfonden, ?rebro, Sweden (2015). The funders had no role in the design and conduct of the study, collection, analysis, and interpretation of the data, and writing and approval of the manuscript. JZ, RC, OA, SOA, UV, FF, and KF conceived of and designed the study; JZ, SD, JC, AME, JF, OA, and SOA contributed to collection of the data; JZ and RC analyzed the data; JZ drafted the manuscript; JZ, RC, SD, JC, AME, JF, OA, SOA, UV, FF, and KF revised the manuscript critically for important intellectual content; All authors read and approved the final manuscript. The authors thank all the subjects who have participated in this clinical trial.