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Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls

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dc.contributor.author Kristiansen, Martin
dc.contributor.author Lindén, Christina
dc.contributor.author Qvarlander, Sara
dc.contributor.author Wåhlin, Anders
dc.contributor.author Ambarki, Khalid
dc.contributor.author Hallberg, Per
dc.contributor.author Eklund, Anders
dc.contributor.author Jóhannesson, Gauti
dc.date.accessioned 2022-04-14T01:02:37Z
dc.date.available 2022-04-14T01:02:37Z
dc.date.issued 2020-11-19
dc.identifier.citation Kristiansen , M , Lindén , C , Qvarlander , S , Wåhlin , A , Ambarki , K , Hallberg , P , Eklund , A & Jóhannesson , G 2020 , ' Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls ' , Acta Ophthalmologica , vol. 99 , no. 5 , pp. e679-e685 . https://doi.org/10.1111/aos.14673
dc.identifier.issn 1755-375X
dc.identifier.other PURE: 42893943
dc.identifier.other PURE UUID: 6970576d-a52a-4124-bd93-8b197fca7013
dc.identifier.other Scopus: 85096671492
dc.identifier.other unpaywall: 10.1111/aos.14673
dc.identifier.uri https://hdl.handle.net/20.500.11815/3062
dc.description Publisher Copyright: © 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation Acknowledgements: This study was presented in part at ARVO 2018 in Honolulu, Hawaii. Financial support was provided through regional agreements between Umeå University and Vasterbotten County Council and also by grants from Knut and Alice Wallenberg Foundation, Crown Princess Margareta’s Foundation, Ogonfonden, Insamlingsstiftelserna vid Umeå universitet, the Swedish Medical Society Foundation, the Cronqvist Foundation and Swedish Society for Medical Research. The funding organizations had no role in the design or conduct of this research. Financial disclosures: Dr Jóhannesson has received speaking honoraria and/or consulting fees from Topcon, Thea, Santen, Allergan, Alcon/Novartis and is equity owner in Oculis™. Khalid Ambarki is an employee of Siemens Healthineers, work related to this study was performed prior to or outside of his duties at Siemens. Other authors have no financial disclosures.
dc.description.abstract Purpose: To examine feasibility of phase-contrast magnetic resonance imaging (PCMRI) and to assess blood flow rate in the ophthalmic artery (OA) in patients with normal tension glaucoma (NTG) compared with healthy controls. Methods: Sixteen patients with treated NTG and 16 age- and sex-matched healthy controls underwent PCMRI using a 3-Tesla scanner and ophthalmological examinations. OA blood flow rate was measured using a 2D PCMRI sequence with a spatial resolution of 0.35 mm2. Results: The blood flow rate in the NTG group was 9.6 ± 3.9 ml/min [mean ± SD] compared with 11.9 ± 4.8 ml/min in the control group. Resistance Index (RI) and Pulsatility Index (PI) were 0.73 ± 0.08 and 1.36 ± 0.29, respectively, in the NTG group and 0.68 ± 0.13 and 1.22 ± 0.40, respectively, in the healthy group. The mean visual field index (VFI) was 46% ± 25 for the worse NTG eyes. The measured differences observed between the NTG group and the control group in blood flow rate (p = 0.12), RI (p = 0.18) and PI (p = 0.27) were non-significant. Conclusions: This case–control study, using PCMRI, showed a slight, but non-significant, reduction in OA blood flow rate in the NTG patients compared with the healthy controls. These results indicate that blood flow may be of importance in the pathogenesis of NTG. Considering that only a limited portion of the total OA blood flow supplies the ocular system and the large inter-individual differences, a larger study or more advanced PCMRI technique might give the answer.
dc.format.extent e679-e685
dc.language.iso en
dc.relation.ispartofseries Acta Ophthalmologica; 99(5)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Gláka
dc.subject Augnsjúkdómar
dc.subject Segulómun
dc.subject Blóðflæði
dc.subject Blóðflæði
dc.subject blood flow
dc.subject glaucoma
dc.subject magnetic resonance imaging
dc.subject normal tension glaucoma
dc.subject ophthalmic artery
dc.subject Prospective Studies
dc.subject Ultrasonography, Doppler, Color
dc.subject Blood Flow Velocity/physiology
dc.subject Humans
dc.subject Magnetic Resonance Imaging/methods
dc.subject Male
dc.subject Feasibility Studies
dc.subject Low Tension Glaucoma/diagnosis
dc.subject Intraocular Pressure/physiology
dc.subject Ophthalmic Artery/diagnostic imaging
dc.subject Female
dc.subject ROC Curve
dc.subject Aged
dc.subject Ophthalmology
dc.title Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33210819
dc.identifier.doi https://doi.org/10.1111/aos.14673
dc.relation.url http://www.scopus.com/inward/record.url?scp=85096671492&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine

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