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Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls

Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls


Title: Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls
Author: Kristiansen, Martin
Lindén, Christina
Qvarlander, Sara
Wåhlin, Anders
Ambarki, Khalid
Hallberg, Per
Eklund, Anders
Jóhannesson, Gauti
Date: 2020-11-19
Language: English
Scope: e679-e685
Department: Faculty of Medicine
Series: Acta Ophthalmologica; 99(5)
ISSN: 1755-375X
DOI: https://doi.org/10.1111/aos.14673
Subject: Gláka; Augnsjúkdómar; Segulómun; Blóðflæði; Blóðflæði; blood flow; glaucoma; magnetic resonance imaging; normal tension glaucoma; ophthalmic artery; Prospective Studies; Ultrasonography, Doppler, Color; Blood Flow Velocity/physiology; Humans; Magnetic Resonance Imaging/methods; Male; Feasibility Studies; Low Tension Glaucoma/diagnosis; Intraocular Pressure/physiology; Ophthalmic Artery/diagnostic imaging; Female; ROC Curve; Aged; Ophthalmology
URI: https://hdl.handle.net/20.500.11815/3062

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Citation:

Kristiansen , M , Lindén , C , Qvarlander , S , Wåhlin , A , Ambarki , K , Hallberg , P , Eklund , A & Jóhannesson , G 2020 , ' Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls ' , Acta Ophthalmologica , vol. 99 , no. 5 , pp. e679-e685 . https://doi.org/10.1111/aos.14673

Abstract:

Purpose: To examine feasibility of phase-contrast magnetic resonance imaging (PCMRI) and to assess blood flow rate in the ophthalmic artery (OA) in patients with normal tension glaucoma (NTG) compared with healthy controls. Methods: Sixteen patients with treated NTG and 16 age- and sex-matched healthy controls underwent PCMRI using a 3-Tesla scanner and ophthalmological examinations. OA blood flow rate was measured using a 2D PCMRI sequence with a spatial resolution of 0.35 mm2. Results: The blood flow rate in the NTG group was 9.6 ± 3.9 ml/min [mean ± SD] compared with 11.9 ± 4.8 ml/min in the control group. Resistance Index (RI) and Pulsatility Index (PI) were 0.73 ± 0.08 and 1.36 ± 0.29, respectively, in the NTG group and 0.68 ± 0.13 and 1.22 ± 0.40, respectively, in the healthy group. The mean visual field index (VFI) was 46% ± 25 for the worse NTG eyes. The measured differences observed between the NTG group and the control group in blood flow rate (p = 0.12), RI (p = 0.18) and PI (p = 0.27) were non-significant. Conclusions: This case–control study, using PCMRI, showed a slight, but non-significant, reduction in OA blood flow rate in the NTG patients compared with the healthy controls. These results indicate that blood flow may be of importance in the pathogenesis of NTG. Considering that only a limited portion of the total OA blood flow supplies the ocular system and the large inter-individual differences, a larger study or more advanced PCMRI technique might give the answer.

Description:

Publisher Copyright: © 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation Acknowledgements: This study was presented in part at ARVO 2018 in Honolulu, Hawaii. Financial support was provided through regional agreements between Umeå University and Vasterbotten County Council and also by grants from Knut and Alice Wallenberg Foundation, Crown Princess Margareta’s Foundation, Ogonfonden, Insamlingsstiftelserna vid Umeå universitet, the Swedish Medical Society Foundation, the Cronqvist Foundation and Swedish Society for Medical Research. The funding organizations had no role in the design or conduct of this research. Financial disclosures: Dr Jóhannesson has received speaking honoraria and/or consulting fees from Topcon, Thea, Santen, Allergan, Alcon/Novartis and is equity owner in Oculis™. Khalid Ambarki is an employee of Siemens Healthineers, work related to this study was performed prior to or outside of his duties at Siemens. Other authors have no financial disclosures.

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