dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Þorleifsdóttir, Ragna Hlín |
dc.contributor.author |
Sigurðardóttir, Sigrún Laufey |
dc.contributor.author |
Sigurgeirsson, Bárður |
dc.contributor.author |
Ólafsson, Jón Hjaltalín |
dc.contributor.author |
Sigurðsson, Martin Ingi |
dc.contributor.author |
Petersen, Hannes |
dc.contributor.author |
Guðjónsson, Jóhann Elí, |
dc.contributor.author |
Johnston, Andrew |
dc.contributor.author |
Valdimarsson, Helgi |
dc.date.accessioned |
2017-05-31T16:13:42Z |
dc.date.available |
2017-05-31T16:13:42Z |
dc.date.issued |
2017 |
dc.identifier.citation |
Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial. 2017, 97 (3):340-345 Acta Derm. Venereol.doi:10.2340/00015555-2562 |
dc.identifier.issn |
0001-5555 |
dc.identifier.issn |
1651-2057 (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/284 |
dc.description.abstract |
Psoriasis is a chronic inflammatory skin disease with profound effects on patients’ health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis. |
dc.description.sponsorship |
This study was supported in part by the Icelandic Research Fund and Landspitali University Hospital Research Fund. AJ is supported by NIH K01 AR064765, the National Psoriasis Foundation USA and the Babcock Memorial Trust. JEG is supported by NIH K08 AR060802, R01 AR069071, The A. Alfred Taubman Medical Research Institute as the Kenneth and Frances Eisenberg Emerging Scholar Award, and the Doris Duke Charitable Foundation Grant (#2013106). The funding institutions had no role in the study. |
dc.format.extent |
340-345 |
dc.language.iso |
en |
dc.publisher |
Acta Dermato-Venereologica |
dc.relation.ispartofseries |
Acta Dermato Venereologica;97(3) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Psoriasis |
dc.subject |
Streptococcal throat infection |
dc.subject |
Tonsillectomy |
dc.subject |
Sóríasis |
dc.subject |
Háls-, nef- og eyrnasjúkdómar |
dc.title |
Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the CC BY-NC license |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Acta Dermato Venereologica |
dc.identifier.doi |
10.2340/00015555-2562 |
dc.relation.url |
https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2562 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |