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Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial

Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial


Titill: Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial
Höfundur: Þorleifsdóttir, Ragna Hlín
Sigurðardóttir, Sigrún Laufey
Sigurgeirsson, Bárður   orcid.org/0000-0002-9733-9742
Ólafsson, Jón Hjaltalín
Sigurðsson, Martin Ingi
Petersen, Hannes   orcid.org/0000-0002-2327-523X
Guðjónsson, Jóhann Elí,
Johnston, Andrew
Valdimarsson, Helgi
Útgáfa: 2017
Tungumál: Enska
Umfang: 340-345
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Acta Dermato Venereologica;97(3)
ISSN: 0001-5555
1651-2057 (eISSN)
DOI: 10.2340/00015555-2562
Efnisorð: Psoriasis; Streptococcal throat infection; Tonsillectomy; Sóríasis; Háls-, nef- og eyrnasjúkdómar
URI: https://hdl.handle.net/20.500.11815/284

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Tilvitnun:

Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial. 2017, 97 (3):340-345 Acta Derm. Venereol.doi:10.2340/00015555-2562

Útdráttur:

Psoriasis is a chronic inflammatory skin disease with profound effects on patients’ health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis.

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This is an open access article under the CC BY-NC license

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