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Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes

Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes


Title: Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes
Author: Tryggvadóttir, Ellen Alma
Gunnarsdóttir, Ingibjörg
Birgisdóttir, Bryndís Eva
Hrólfsdottir, Laufey
Landberg, Rikard
Hreiðarsdóttir, Ingibjörg Th
Harðardóttir, Hildur
Halldórsson, Þórhallur Ingi
Date: 2021-08-04
Language: English
Scope:
School: School of Health Sciences
Department: Faculty of Food Science and Nutrition
Other departments
Faculty of Medicine
Series: BMJ Open Diabetes Research and Care; 9(1)
ISSN: 2052-4897
DOI: https://doi.org/10.1136/bmjdrc-2021-002326
Subject: Sykursýki; Meðganga; Fitusýrur; Mataræði; diabetes; diet; fatty acids; gestational; pregnancy; Endocrinology, Diabetes and Metabolism
URI: https://hdl.handle.net/20.500.11815/2744

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Citation:

Tryggvadóttir , E A , Gunnarsdóttir , I , Birgisdóttir , B E , Hrólfsdottir , L , Landberg , R , Hreiðarsdóttir , I T , Harðardóttir , H & Halldórsson , Þ I 2021 , ' Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes ' , BMJ Open Diabetes Research and Care , vol. 9 , no. 1 , e002326 . https://doi.org/10.1136/bmjdrc-2021-002326

Abstract:

Introduction Fatty acid (FA) concentrations have previously been associated with gestational diabetes mellitus (GDM). However, few studies on GDM have examined FA profiles in early pregnancy or before diagnosis. This study aimed to compare early pregnancy plasma FA profiles of women with and without GDM diagnoses as well as their reported dietary consumption. Research design and methods The subjects comprised 853 women from the prospective study: Pregnant Women in Iceland II (PREWICE II), attending their 11-14 weeks ultrasound appointment in 2017-2018. During the visit, blood samples were collected for plasma FA analysis, and dietary habits were assessed using a short food frequency questionnaire. Information on GDM diagnoses was then later extracted from medical records. Differences in FA profile between GDM cases and non-cases were evaluated using the Mann-Whitney U test. Results GDM was diagnosed in 127 women (14.9%). Concentrations of saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids (PUFA) n-6, PUFA n-3 and total FA were higher in the women who later developed GDM compared with those who did not (p≤0.05). The medians for total FA were 2898 μg/mL for the women with GDM and 2681 μg/mL for those without GDM. Mean adjusted difference for total FA between the groups was 133 μg/mL (95% CI 33 to 233). Similar results were observed in prepregnancy normal-weight women and overweight women/women with obesity. Overall diet quality in early pregnancy appeared to be lower among the women later diagnosed with GDM. Conclusion We found that plasma FA profiles in early pregnancy were different for women later diagnosed with GDM compared with those who were not, independent of the women's body mass index.

Description:

Funding Information: Funding This study was funded by the University of Iceland Research Fund (HI18080069) and the Science Fund of The National University Hospital in Iceland (798381 and 893911). Competing interests None declared. Patient consent for publication Not required. ethics approval The study was approved by the National Bioethics Committee (VSN-17-057-S1) and the Medical Directorate of Landspitali University Hospital (LSH 5-17). Written consents were obtained from the participants. Provenance and peer review Not commissioned; externally peer reviewed. data availability statement No data are available. Data are not in a repository. Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise. Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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