dc.contributor |
Háskólinn í Reykjavík |
dc.contributor |
Reykjavik University |
dc.contributor.author |
Desmirean, Minodora |
dc.contributor.author |
Rauch, Sebastian |
dc.contributor.author |
Jurj, Ancuta |
dc.contributor.author |
Pasca, Sergiu |
dc.contributor.author |
Iluta, Sabina |
dc.contributor.author |
Teodorescu, Patric |
dc.contributor.author |
Berce, Cristian |
dc.contributor.author |
Zimta, Alina-Andreea |
dc.contributor.author |
Turcas, Cristina |
dc.contributor.author |
Tigu, Adrian-Bogdan |
dc.contributor.author |
Moldovan, Cristian |
dc.contributor.author |
Paris, Irene |
dc.contributor.author |
Steinheber, Jakob |
dc.contributor.author |
Richlitzki, Cedric |
dc.contributor.author |
Constantinescu, Catalin |
dc.contributor.author |
Sigurjonsson, Olafur |
dc.contributor.author |
Dima, Delia |
dc.contributor.author |
Petrushev, Bobe |
dc.contributor.author |
Tomuleasa, Ciprian |
dc.date.accessioned |
2021-03-24T15:56:05Z |
dc.date.available |
2021-03-24T15:56:05Z |
dc.date.issued |
2020-10-24 |
dc.identifier.citation |
Desmirean, M., Rauch, S., Jurj, A., Pasca, S., Iluta, S., Teodorescu, P., Berce, C., Zimta, A.-A., Turcas, C., Tigu, A.-B., Moldovan, C., Paris, I., Steinheber, J., Richlitzki, C., Constantinescu, C., Sigurjonsson, O. E., Dima, D., Petrushev, B., & Tomuleasa, C. (2020). B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Journal of Clinical Medicine, 9(11), 3412. https://doi.org/10.3390/jcm9113412 |
dc.identifier.issn |
2077-0383 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2514 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Malignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tissues they infiltrate. The immune system has developed mechanisms to protect the normal tissue from malignant growth. In this review, we aim to explain how T lymphocyte-driven control is linked to tumor development and describe the tumor-suppressive components of the resistant framework. This manuscript brings forward a new insight with regard to intercellular and intracellular signaling, the immune microenvironment, the impact of therapy, and its predictive implications. A better understanding of the key components of the lymphoma environment is important to properly assess the role of both B and T lymphocytes, as well as their interplay, just as two legendary boxers face each other in a heavyweight title final, as was the case of Ali versus Foreman. |
dc.description.sponsorship |
The research on the lymphoma microenvironment was funded by an internal grant of the Iuliu Hatieganu University, School of Doctoral Studies (PCD 2018-2021) (Minodora Desmirean), under the frame of European Social Found, Human Capital Operational Program 2014-2020, project no. POCU/380/6/13/125171 (Minodora Desmirean) and the Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, Project No. PN-III-P4-ID-PCCF-2016-0112 within PNCDI III, by an award for Young Research Teams 2020-2022 (Grant No. PN-III-P1-1.1-TE-2019-0271) (both Ciprian Tomuleasa) as well as by an international collaborative grant of the European Economic Space between Romania and Iceland 2020-2022 (Grant No. 19-COP-0031) (Ciprian Tomuleasa). |
dc.format.extent |
3412 |
dc.language.iso |
en |
dc.publisher |
MDPI AG |
dc.relation.ispartofseries |
Journal of Clinical Medicine;9(11) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Malignant lymphomas |
dc.subject |
Tumor microenvironment |
dc.subject |
Lymphocyte inter-talk |
dc.subject |
B lymphocytes |
dc.subject |
T-Lymphocytes |
dc.subject |
Eitilfrumukrabbamein |
dc.subject |
Eitlar |
dc.subject |
Æxli |
dc.subject |
Frumur |
dc.subject |
T-frumur |
dc.subject |
Ónæmisfræði |
dc.title |
B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.description.version |
"Peer Reviewed" |
dc.identifier.doi |
10.3390/jcm9113412 |
dc.relation.url |
https://www.mdpi.com/2077-0383/9/11/3412/pdf |
dc.contributor.department |
Verkfræðideild (HR) |
dc.contributor.department |
Department of Engineering (RU) |
dc.contributor.school |
Tæknisvið (HR) |
dc.contributor.school |
School of Technology (RU) |