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Browsing IRIS by Author "Saevarsdottir, Saedis"

Now showing items 1-9 of 9

Abatacept in rheumatoid arthritis : Survival on drug, clinical outcomes, and their predictors - Data from a large national quality register

Cagnotto, Giovanni; Willim, Minna; Nilsson, Jan Åke; Compagno, Michele; Jacobsson, Lennart T.H.; Saevarsdottir, Saedis; Turesson, Carl (2020-01-22)

Background: There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. ...
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells : Implications for a Bacterial Origin in RA Etiology

Sherina, Natalia; de Vries, Charlotte; Kharlamova, Nastya; Sippl, Natalie; Jiang, Xia; Brynedal, Boel; Kindstedt, Elin; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Stålesen, Ragnhild; Saevarsdottir, Saedis; Holmdahl, Rikard; Hensvold, Aase; Johannsen, Gunnar; Eriksson, Kaja; Sallusto, Federica; Catrina, Anca I.; Rönnelid, Johan; Grönwall, Caroline; Yucel-Lindberg, Tülay; Alfredsson, Lars; Klareskog, Lars; Piccoli, Luca; Malmström, Vivianne; Amara, Khaled; Lundberg, Karin (2022-04-20)

Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39

Spiliopoulou, Athina; Colombo, Marco; Plant, Darren; Nair, Nisha; Cui, Jing; Coenen, Marieke J.H.; Ikari, Katsunori; Yamanaka, Hisashi; Saevarsdottir, Saedis; Padyukov, Leonid; Bridges, S. Louis; Kimberly, Robert P.; Okada, Yukinori; Van Riel, Piet L.C.M.; Wolbink, Gertjan; Van Der Horst-Bruinsma, Irene E.; De Vries, Niek; Tak, Paul P.; Ohmura, Koichiro; Canhão, Helena; Guchelaar, Henk Jan; Huizinga, Tom W.J.; Criswell, Lindsey A.; Raychaudhuri, Soumya; Weinblatt, Michael E.; Wilson, Anthony G.; Mariette, Xavier; Isaacs, John D.; Morgan, Ann W.; Pitzalis, Costantino; Barton, Anne; Mckeigue, Paul (2019-08-01)

Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these ...
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements : Results From the UK Biobank Resource

Styrkarsdottir, Unnur; Lund, Sigrun H; Thorleifsson, Gudmar; Saevarsdottir, Saedis; Gudbjartsson, Daniel F; Thorsteinsdottir, Unnur; Stefansson, Kari (2023-04)

OBJECTIVE: The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an ...
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis : Emulating a Randomized Trial in Observational Data

Barbulescu, Andrei; Askling, Johan; Saevarsdottir, Saedis; Kim, Seoyoung C.; Frisell, Thomas (2022-06-23)

Observational studies are often considered unreliable for evaluating relative treatment effectiveness, but it has been suggested that following target trial protocols could reduce bias. Using observational data from patients with rheumatoid arthritis ...
Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapy : a Swedish observational nationwide study

Tidblad, Liselotte; Westerlind, Helga; Delcoigne, Bénédicte; Askling, Johan; Saevarsdottir, Saedis (2023-12-20)

OBJECTIVES: This study aims to examine whether comorbidities affect the likelihood of reaching primary remission on methotrexate monotherapy as the first disease-modifying antirheumatic drug (DMARD) in early rheumatoid arthritis (RA). METHODS: We used ...
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?

Sysojev, Anton Öberg; Frisell, Thomas; Delcoigne, Bénédicte; Saevarsdottir, Saedis; Askling, Johan; Westerlind, Helga (2022-08-06)

Objectives: To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability. Methods: First-degree relative pairs diagnosed ...
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study

Westerlind, Helga; Palmqvist, Ida; Saevarsdottir, Saedis; Alfredsson, Lars; Klareskog, Lars; Di Giuseppe, Daniela (2021-08-07)

BACKGROUND: Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, ...
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis : results from the Swedish EIRA study

Hedenstierna, Louise; Hedström, Anna Karin; Klareskog, Lars; Di Giuseppe, Daniela; Alfredsson, Lars; Askling, Johan; Ernestam, Sofia; Saevarsdottir, Saedis; Ljung, Lotta (2022-08-23)

Objectives: To investigate the association between psychosocial vulnerability, defined as either low social support or low decision latitude at work, and disease remission at 3, 12, and 60 months in patients with rheumatoid arthritis (RA). Methods: ...

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