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Fletta eftir höfundi "Rafnar, Thorunn"

Fletta eftir höfundi "Rafnar, Thorunn"

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    Functional dissection of inherited non-coding variation influencing multiple myeloma risk 
    Ajore, Ram; Niroula, Abhishek; Pertesi, Maroulio; Cafaro, Caterina; Thodberg, Malte; Went, Molly; Bao, Erik L.; Duran-Lozano, Laura; Lopez de Lapuente Portilla, Aitzkoa; Olafsdottir, Thorunn; Ugidos-Damboriena, Nerea; Magnusson, Olafur; Samur, Mehmet; Lareau, Caleb A.; Halldorsson, Gisli H.; Thorleifsson, Gudmar; Norddahl, Gudmundur L.; Gunnarsdottir, Kristbjorg; Försti, Asta; Goldschmidt, Hartmut; Hemminki, Kari; van Rhee, Frits; Kimber, Scott; Sperling, Adam S.; Kaiser, Martin; Anderson, Kenneth; Jonsdottir, Ingileif; Munshi, Nikhil; Rafnar, Thorunn; Waage, Anders; Weinhold, Niels; Thorsteinsdottir, Unnur; Sankaran, Vijay G.; Stefansson, Kari; Houlston, Richard; Nilsson, Björn (2022-01-10)
    Thousands of non-coding variants have been associated with increased risk of human diseases, yet the causal variants and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel reporter assays (MPRA), expression ...
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    Genetic architecture of band neutrophil fraction in Iceland 
    Oskarsson, Gudjon R.; Magnússon, Magnús Karl; Oddson, Ásmundur; Jensson, Brynjar O; Friðriksdóttir, Rún; Arnadottir, Gudny A; Katrinardottir, Hildigunnur; Rögnvaldsson, Sölvi; Halldórsson, Gísli Hreinn; Sveinbjörnsson, Gardar; Ivarsdottir, Erna V.; Stefánsdóttir, Lilja; Ferkingstad, Egil; Norland, Kristjan; Tragante, Vinicius; Sæmundsdóttir, Jóna; Jónasdóttir, Áslaug; Jonasdottir, Adalbjorg; Sigurjonsdottir, Svanhvit; Petursdottir, Karen O.; Davidsson, Olafur B; Rafnar, Thorunn; Hólm, Hilma; Ólafsson, Ísleifur; Önundarson, Páll Torfi; Viðarsson, Brynjar; Sigurdardottir, Olof G.; Másson, Gísli; Gudbjartsson, Daniel Fannar; Jónsdóttir, Ingileif; Norddahl, Gudmundur L.; Þorsteinsdóttir, Unnur; Sulem, Patrick; Stefánsson, Kári (2022-06-01)
    The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils, called ...
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    Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis 
    Stacey, Simon N.; Zink, Florian; Halldórsson, Gísli Hreinn; Stefánsdóttir, Lilja; Guðjónsson, Sigurjón Axel; Einarsson, Gudmundur; Hjörleifsson, Grimur; Eiríksdóttir, Þjóðbjörg; Helgadottir, Anna; Björnsdottir, Gyda; Thorgeirsson, Thorgeir E.; Ólafsdóttir, Þórunn Ásta; Jónsdóttir, Ingileif; Gretarsdottir, Solveig; Tragante, Vinicius; Magnússon, Magnús Karl; Jonsson, Hakon; Gudmundsson, Julius; Olafsson, Sigurgeir; Holm, Hilma; Gudbjartsson, Daniel F.; Sulem, Patrick; Helgason, Agnar Sturla; Þorsteinsdóttir, Unnur; Tryggvadottir, Laufey; Rafnar, Thorunn; Melsted, Páll; Úlfarsson, Magnús Örn; Viðarsson, Brynjar; Thorleifsson, Gudmar; Stefánsson, Kári (2023-12)
    Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of 45,510 Icelandic and 130,709 UK Biobank participants combined with a mutational ...
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    Germline variants at SOHLH2 influence multiple myeloma risk 
    Duran-Lozano, Laura; Thorleifsson, Gudmar; Lopez de Lapuente Portilla, Aitzkoa; Niroula, Abhishek; Went, Molly; Thodberg, Malte; Pertesi, Maroulio; Ajore, Ram; Cafaro, Caterina; Olason, Pall I.; Stefansdottir, Lilja; Bragi Walters, G.; Halldorsson, Gisli H.; Turesson, Ingemar; Kaiser, Martin F.; Weinhold, Niels; Abildgaard, Niels; Andersen, Niels Frost; Mellqvist, Ulf Henrik; Waage, Anders; Juul-Vangsted, Annette; Thorsteinsdottir, Unnur; Hansson, Markus; Houlston, Richard; Rafnar, Thorunn; Stefansson, Kari; Nilsson, Björn (2021-04)
    Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a genome-wide association study ...
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    Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis 
    Magnússon, Magnús Ingvi; Agnarsson, Bjarni Agnar; Jónasson, Jón Gunnlaugur; Tryggvason, Þórður; Aeffner, Famke; le Roux, Louise; Magnusdottir, Droplaug N.; Gunnarsdóttir, Helga Sigrún; Alexíusdóttir, Kristín K.; Gunnarsdottir, Kristbjorg; Söebech, Emilia; Runarsdottir, Hjaltey; Jónsdóttir, Erna María; Kristinsdóttir, Bjarney Sif; Olafsson, Sigurgeir; Knutsdottir, Hildur; Þorsteinsdóttir, Unnur; Úlfarsson, Magnús Örn; Guðbjartsson, Daníel Fannar; Saemundsdottir, Jona; Magnusson, Olafur T.; Norddahl, Gudmundur L.; Watson, J. E.Vivienne; Rafnar, Thorunn; Lund, Sigrún Helga; Stefánsson, Kári (2023-10-19)
    Background: The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in the blood. As some of these factors ...
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    Large-scale plasma proteomics comparisons through genetics and disease associations 
    Eldjarn, Grimur Hjorleifsson; Ferkingstad, Egil; Lund, Sigrun H.; Helgason, Hannes; Magnusson, Olafur Th; Gunnarsdottir, Kristbjorg; Olafsdottir, Thorunn A.; Halldorsson, Bjarni V.; Olason, Pall I.; Zink, Florian; Gudjonsson, Sigurjon A.; Sveinbjornsson, Gardar; Magnusson, Magnus I.; Helgason, Agnar; Oddsson, Asmundur; Halldorsson, Gisli H.; Magnusson, Magnus K.; Sævarsdóttir, Sædís; Eiriksdottir, Thjodbjorg; Masson, Gisli; Stefansson, Hreinn; Jonsdottir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Melsted, Pall; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Thorleifsson, Gudmar; Ulfarsson, Magnus O.; Gudbjartsson, Daniel F.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari (2023-10-04)
    High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore ...
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    Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect 
    Styrkársdóttir, Unnur; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Andri Stefánsson, Ólafur; Sævarsdóttir, Sædís; Lund, Sigrún Helga; Rafnar, Thorunn; Hoshijima, Kazuyuki; Novak, Kendra; Oreiro, Natividad; Rego-Perez, Ignacio; Hansen, Channing; Kazmers, Nikolas; Kiemeney, Lambertus A; Blanco, Francisco J; Barker, Tyler; Kloppenburg, Margreet; Jurynec, Michael J; Gudbjartsson, Daniel F; Jónsson, Helgi; Þorsteinsdóttir, Unnur; Stefánsson, Kári (2023-06)
    OBJECTIVES: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been associated with hand OA but none with EHOA. ...
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    Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study 
    Holm, Hilma; Ivarsdottir, Erna V; Olafsdottir, Thorhildur; Thorolfsdottir, Rosa; Eythorsson, Elias; Norland, Kristjan; Gisladottir, Rosa; Jonsdottir, Gudrun; Unnsteinsdottir, Unnur; Sveinsdottir, Kristin E; Jonsson, Benedikt A; Andresdottir, Margret; Arnar, Davíð Ottó; Arnthorsson, Asgeir O; Birgisdottir, Kolbrún; Bjarnadottir, Kristbjorg; Bjarnadottir, Solveig; Bjornsdottir, Gyda; Einarsson, Gudmundur; Eiriksdottir, Berglind; Gardarsdottir, Elisabet Eir; Gíslason, Þórarinn; Gottfreðsson, Magnús; Gudmundsdottir, Steinunn; Gudmundsson, Julius; Gunnarsdottir, Kristbjorg; Helgadottir, Anna; Helgason, Dadi; Hinriksdottir, Ingibjorg; Ingvarsson, Ragnar Freyr; Jonasdottir, Sigga S; Jónsdóttir, Ingileif; Karlsdottir, Tekla H; Kristinsdottir, Anna M; Kristinsson, Sigurður Yngvi; Kristjansdottir, Steinunn; Löve, Þorvarður Jón; Lúðvíksdóttir, Dóra; Masson, Gisli; Norddahl, Gudmundur; Olafsdottir, Thorunn; Ólafsson, Ísleifur; Rafnar, Thorunn; Runólfsdóttir, Hrafnhildur L.; Saemundsdottir, Jona; Sigurbjornsson, Svanur; Sigurdardottir, Kristin; Sigurðsson, Engilbert; Sigurðsson, Martin Ingi; Sigurdsson, Emil L; Steinthorsdottir, Valgerdur; Sveinbjornsson, Gardar; Thorarensen, Emil A; Thorbjornsson, Bjarni; Thorsteinsdottir, Brynja; Tragante, Vinicius; Ulfarsson, Magnus O; Stefansson, Hreinn; Gislason, Thorsteinn; Kristjansson, Mar; Palsson, Runolfur; Sulem, Patrick; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Gudbjartsson, Daniel F; Stefansson, Kari (2023-07-06)
    BACKGROUND: Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear. METHODS: We invited all 3098 adults who tested SARS-CoV-2 positive in Iceland before October 2020 to the deCODE Health Study. We ...
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    Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis 
    Oskarsson, Gudjon R.; Oddsson, Asmundur; Magnusson, Magnus K.; Kristjansson, Ragnar P.; Halldorsson, Gisli H.; Ferkingstad, Egil; Zink, Florian; Helgadottir, Anna; Ivarsdottir, Erna V.; Arnadottir, Gudny A.; Jensson, Brynjar O.; Katrinardottir, Hildigunnur; Sveinbjornsson, Gardar; Kristinsdottir, Anna M.; Lee, Amy L.; Saemundsdottir, Jona; Stefansdottir, Lilja; Sigurdsson, Jon K.; Davidsson, Olafur B.; Benonisdottir, Stefania; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Jonsson, Stefan; Gudmundsson, Reynir L.; Asselbergs, Folkert W.; Tragante, Vinicius; Gunnarsson, Bjarni; Masson, Gisli; Thorleifsson, Gudmar; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Onundarson, Pall T.; Gudbjartsson, Daniel F.; Norddahl, Gudmundur L.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari (2020-04-23)
    Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of ...
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    Predicting the probability of death using proteomics 
    Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...