Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study

Holm, Hilma; Ivarsdottir, Erna V; Olafsdottir, Thorhildur; Thorolfsdottir, Rosa; Eythorsson, Elias; Norland, Kristjan; Gisladottir, Rosa; Jonsdottir, Gudrun; Unnsteinsdottir, Unnur; Sveinsdottir, Kristin E; Jonsson, Benedikt A; Andresdottir, Margret; Arnar, Davíð Ottó; Arnthorsson, Asgeir O; Birgisdottir, Kolbrún; Bjarnadottir, Kristbjorg; Bjarnadottir, Solveig; Bjornsdottir, Gyda; Einarsson, Gudmundur; Eiriksdottir, Berglind; Gardarsdottir, Elisabet Eir; Gíslason, Þórarinn; Gottfreðsson, Magnús; Gudmundsdottir, Steinunn; Gudmundsson, Julius; Gunnarsdottir, Kristbjorg; Helgadottir, Anna; Helgason, Dadi; Hinriksdottir, Ingibjorg; Ingvarsson, Ragnar Freyr; Jonasdottir, Sigga S; Jónsdóttir, Ingileif; Karlsdottir, Tekla H; Kristinsdottir, Anna M; Kristinsson, Sigurður Yngvi; Kristjansdottir, Steinunn; Löve, Þorvarður Jón; Lúðvíksdóttir, Dóra; Masson, Gisli; Norddahl, Gudmundur; Olafsdottir, Thorunn; Ólafsson, Ísleifur; Rafnar, Thorunn; Runólfsdóttir, Hrafnhildur L.; Saemundsdottir, Jona; Sigurbjornsson, Svanur; Sigurdardottir, Kristin; Sigurðsson, Engilbert; Sigurðsson, Martin Ingi; Sigurdsson, Emil L; Steinthorsdottir, Valgerdur; Sveinbjornsson, Gardar; Thorarensen, Emil A; Thorbjornsson, Bjarni; Thorsteinsdottir, Brynja; Tragante, Vinicius; Ulfarsson, Magnus O; Stefansson, Hreinn; Gislason, Thorsteinn; Kristjansson, Mar; Palsson, Runolfur; Sulem, Patrick; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Gudbjartsson, Daniel F; Stefansson, Kari

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Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study

Titill:	Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study
Höfundur:	Holm, Hilma orcid.org/0000-0002-9517-6636 Ivarsdottir, Erna V Olafsdottir, Thorhildur Thorolfsdottir, Rosa Eythorsson, Elias Norland, Kristjan Gisladottir, Rosa Jonsdottir, Gudrun Unnsteinsdottir, Unnur Sveinsdottir, Kristin E ... 56 fleiri höfundar Sýna alla höfunda Jonsson, Benedikt A Andresdottir, Margret Arnar, Davíð Ottó Arnthorsson, Asgeir O Birgisdottir, Kolbrún Bjarnadottir, Kristbjorg Bjarnadottir, Solveig Bjornsdottir, Gyda orcid.org/0000-0002-8100-0306 Einarsson, Gudmundur Eiriksdottir, Berglind Gardarsdottir, Elisabet Eir Gíslason, Þórarinn Gottfreðsson, Magnús Gudmundsdottir, Steinunn Gudmundsson, Julius orcid.org/0000-0003-2517-4763 Gunnarsdottir, Kristbjorg Helgadottir, Anna orcid.org/0000-0002-1806-2467 Helgason, Dadi orcid.org/0000-0002-0162-366X Hinriksdottir, Ingibjorg Ingvarsson, Ragnar Freyr Jonasdottir, Sigga S Jónsdóttir, Ingileif Karlsdottir, Tekla H Kristinsdottir, Anna M Kristinsson, Sigurður Yngvi Kristjansdottir, Steinunn Löve, Þorvarður Jón orcid.org/0000-0002-2680-6120 Lúðvíksdóttir, Dóra Masson, Gisli Norddahl, Gudmundur Olafsdottir, Thorunn Ólafsson, Ísleifur Rafnar, Thorunn orcid.org/0000-0003-0491-7046 Runólfsdóttir, Hrafnhildur L. Saemundsdottir, Jona Sigurbjornsson, Svanur Sigurdardottir, Kristin Sigurðsson, Engilbert Sigurðsson, Martin Ingi Sigurdsson, Emil L Steinthorsdottir, Valgerdur orcid.org/0000-0003-1846-6274 Sveinbjornsson, Gardar orcid.org/0000-0003-2429-9468 Thorarensen, Emil A Thorbjornsson, Bjarni Thorsteinsdottir, Brynja Tragante, Vinicius Ulfarsson, Magnus O Stefansson, Hreinn orcid.org/0000-0002-9331-6666 Gislason, Thorsteinn Kristjansson, Mar Palsson, Runolfur orcid.org/0000-0001-6763-1702 Sulem, Patrick orcid.org/0000-0001-7123-6123 Thorsteinsdottir, Unnur Thorgeirsson, Gudmundur orcid.org/0000-0002-7146-1395 Gudbjartsson, Daniel F Stefansson, Kari orcid.org/0000-0003-1676-864X 66 höfundar Sýna færri höfunda
Útgáfa:	2023-07-06
Tungumál:	Enska
Umfang:	1724287
Svið:	Health Sciences
Deild:	Faculty of Icelandic and Comparative Cultural Studies Faculty of Electrical and Computer Engineering Other departments Faculty of Medicine Internal Medicine and Emergency Services Faculty of Philosophy, History and Archaeology
Birtist í:	Communications medicine; 3(1)
ISSN:	2730-664X
DOI:	10.1038/s43856-023-00326-5
Efnisorð:	Hjartalæknisfræði; Lungnalæknisfræði; Smitsjúkdómalæknisfræði; Blóðlæknisfræði; Gigtarlæknisfræði; Lífefna- og sameindalíffræði; Geðsjúkdómafræði; Svæfinga- og gjörgæslulæknisfræði
URI:	https://hdl.handle.net/20.500.11815/4435
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Tilvitnun: Holm , H , Ivarsdottir , E V , Olafsdottir , T , Thorolfsdottir , R , Eythorsson , E , Norland , K , Gisladottir , R , Jonsdottir , G , Unnsteinsdottir , U , Sveinsdottir , K E , Jonsson , B A , Andresdottir , M , Arnar , D O , Arnthorsson , A O , Birgisdottir , K , Bjarnadottir , K , Bjarnadottir , S , Bjornsdottir , G , Einarsson , G , Eiriksdottir , B , Gardarsdottir , E E , Gíslason , Þ , Gottfreðsson , M , Gudmundsdottir , S , Gudmundsson , J , Gunnarsdottir , K , Helgadottir , A , Helgason , D , Hinriksdottir , I , Ingvarsson , R F , Jonasdottir , S S , Jónsdóttir , I , Karlsdottir , T H , Kristinsdottir , A M , Kristinsson , S Y , Kristjansdottir , S , Löve , Þ J , Lúðvíksdóttir , D , Masson , G , Norddahl , G , Olafsdottir , T , Ólafsson , Í , Rafnar , T , Runólfsdóttir , H L , Saemundsdottir , J , Sigurbjornsson , S , Sigurdardottir , K , Sigurðsson , E , Sigurðsson , M I , Sigurdsson , E L , Steinthorsdottir , V , Sveinbjornsson , G , Thorarensen , E A , Thorbjornsson , B , Thorsteinsdottir , B , Tragante , V , Ulfarsson , M O , Stefansson , H , Gislason , T , Kristjansson , M , Palsson , R , Sulem , P , Thorsteinsdottir , U , Thorgeirsson , G , Gudbjartsson , D F & Stefansson , K 2023 , ' Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study ' , Communications medicine , vol. 3 , no. 1 , pp. 94 . https://doi.org/10.1038/s43856-023-00326-5
Útdráttur: BACKGROUND: Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear. METHODS: We invited all 3098 adults who tested SARS-CoV-2 positive in Iceland before October 2020 to the deCODE Health Study. We compared multiple symptoms and physical measures between 1706 Icelanders with confirmed prior infection (cases) who participated, and 619 contemporary and 13,779 historical controls. Cases participated in the study 5-18 months after infection. RESULTS: Here we report that 41 of 88 symptoms are associated with prior infection, most significantly disturbed smell and taste, memory disturbance, and dyspnea. Measured objectively, cases had poorer smell and taste results, less grip strength, and poorer memory recall. Differences in grip strength and memory recall were small. No other objective measure associated with prior infection including heart rate, blood pressure, postural orthostatic tachycardia, oxygen saturation, exercise tolerance, hearing, and traditional inflammatory, cardiac, liver, and kidney blood biomarkers. There was no evidence of more anxiety or depression among cases. We estimate the prevalence of long Covid to be 7% at a median of 8 months after infection. CONCLUSIONS: We confirm that diverse symptoms are common months after SARS-CoV-2 infection but find few differences between cases and controls in objective parameters measured. These discrepancies between symptoms and physical measures suggest a more complicated contribution to symptoms related to prior infection than is captured with conventional tests. Traditional clinical assessment is not expected to be particularly informative in relating symptoms to a past SARS-CoV-2 infection.
Athugasemdir: © 2023. The Author(s).