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    Deep learning-based algorithm accurately classifies sleep stages in preadolescent children with sleep-disordered breathing symptoms and age-matched controls 
    Somaskandhan, Pranavan; Leppänen, Timo; Terrill, Philip I; Sigurdardottir, Sigridur; Arnardóttir, Erna Sif; Ólafsdóttir, Kristín Anna; Serwatko, Marta; Sigurðardóttir, Sigurveig Þ; Clausen, Michael Valur; Töyräs, Juha; Korkalainen, Henri (2023-04-14)
    INTRODUCTION: Visual sleep scoring has several shortcomings, including inter-scorer inconsistency, which may adversely affect diagnostic decision-making. Although automatic sleep staging in adults has been extensively studied, it is uncertain whether ...
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    Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality 
    DBDS Genomic Consortium (2023-06-10)
    Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among ...
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    Defining new reference intervals for serum free light chains in individuals with chronic kidney disease : Results of the iStopMM study 
    Long, Þórir Einarsson; Indriðason, Ólafur Skúli; Pálsson, Runólfur; Rögnvaldsson, Sæmundur; Löve, Þorvarður Jón; Thorsteinsdóttir, Sigrún; Sverrisdóttir, Ingigerður S; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni Agnar; Sigurðardóttir, Margrét; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Thordardottir, Asdis Rosa; Eyþórsson, Elías Sæbjörn; Jónsson, Ásbjörn; Gíslason, Gauti Kjartan; Ólafsson, Andri; Steingrímsdóttir, Hlíf; Hultcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Kristinsson, Sigurður Yngvi (2022-09-14)
    Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish a reference interval for FLCs in persons with chronic kidney disease (CKD). A total of 75422 ...
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    Dehumanization of outgroup members and cross-group interactions 
    Borinca, Islam; Assche, Jasper Van; Gronfeldt, Bjarki; Sainz, Mario; Anderson, Joel; Taşbaş, Esra Hatice Oğuz (2023-04-01)
    Subtle and blatant dehumanization exacerbates negative intergroup relations while intergroup contact ameliorates them. An emerging body of research has started to examine the link between intergroup contact and dehumanization as a potential method for ...
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    Dementia risk in the general population : large-scale external validation of prediction models in the AGES-Reykjavik study 
    Vonk, Jet M.J.; Greving, Jacoba P.; Gudnason, Vilmundur; Launer, Lenore J.; Geerlings, Mirjam I. (2021-07-25)
    We aimed to evaluate the external performance of prediction models for all-cause dementia or AD in the general population, which can aid selection of high-risk individuals for clinical trials and prevention. We identified 17 out of 36 eligible published ...
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    Demonstrating trustworthiness when collecting and sharing genomic data : public views across 22 countries 
    Milne, Richard; Morley, Katherine I.; Almarri, Mohamed A.; Anwer, Shamim; Atutornu, Jerome; Baranova, Elena E.; Bevan, Paul; Cerezo, Maria; Cong, Yali; Costa, Alessia; Critchley, Christine; Fernow, Josepine; Goodhand, Peter; Hasan, Qurratulain; Hibino, Aiko; Houeland, Gry; Howard, Heidi C.; Hussain, S. Zakir; Malmgren, Charlotta Ingvoldstad; Izhevskaya, Vera L.; Jędrzejak, Aleksandra; Jinhong, Cao; Kimura, Megumi; Kleiderman, Erika; Leach, Brandi; Liu, Keying; Mascalzoni, Deborah; Mendes, Álvaro; Minari, Jusaku; Nicol, Dianne; Niemiec, Emilia; Patch, Christine; Pollard, Jack; Prainsack, Barbara; Rivière, Marie; Robarts, Lauren; Roberts, Jonathan; Romano, Virginia; Sheerah, Haytham A.; Smith, James; Soulier, Alexandra; Steed, Claire; Stefánsdóttir, Vigdís Fjóla; Tandre, Cornelia; Thorogood, Adrian; Voigt, Torsten H.; Wang, Nan; West, Anne V.; Yoshizawa, Go; Middleton, Anna (2021-12)
    Background: Public trust is central to the collection of genomic and health data and the sustainability of genomic research. To merit trust, those involved in collecting and sharing data need to demonstrate they are trustworthy. However, it is unclear ...
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    Deprescribing practices, habits and attitudes of geriatricians and geriatricians-in-training across Europe : a large web-based survey 
    On Behalf of the EuGMS SIG Pharmacology (2022-12)
    Purpose: To provide an overview of the current deprescribing attitudes, practices, and approaches of geriatricians and geriatricians-in-training across Europe. Methods: An online survey was disseminated among European geriatricians and geriatricians- ...
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    Descent of fetal head during active pushing: secondary analysis of prospective cohort study investigating ultrasound examination before operative vaginal delivery. 
    Kahrs, B H; Usman, S; Ghi, T; Youssef, A; Torkildsen, E A; Lindtjørn, E; Østborg, T B; Benediktsdóttir, Sigurlaug; Brooks, L; Harmsen, L; Salvesen, K Å; Lees, C C; Eggebø, T M (2019-10)
    OBJECTIVES: To investigate if descent of the fetal head during active pushing is associated with duration of operative vaginal delivery, mode of delivery and neonatal outcome in nulliparous women with prolonged second stage of labor. METHODS: This was ...
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    Descent of the presenting part assessed with ultrasound 
    Eggebø, Torbjørn M; Hjartardóttir, Hulda (2024-03)
    Fetal head descent can be expressed as fetal station and engagement. Station is traditionally based on clinical vaginal examination of the distal part of the fetal skull and related to the level of the ischial spines. Engagement is based on a transabdominal ...
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    Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study : Protocol for an Exploratory, Cross-sectional Study 
    Curcic, Jelena; Vallejo, Vanessa; Sorinas, Jennifer; Sverdlov, Oleksandr; Praestgaard, Jens; Piksa, Mateusz; Deurinck, Mark; Erdemli, Gul; Bügler, Maximilian; Tarnanas, Ioannis; Taptiklis, Nick; Cormack, Francesca; Anker, Rebekka; Massé, Fabien; Souillard-Mandar, William; Intrator, Nathan; Molcho, Lior; Madero, Erica; Bott, Nicholas; Chambers, Mieko; Tamory, Josef; Shulz, Matias; Fernandez, Gerardo; Simpson, William; Robin, Jessica; Snædal, Jón G; Cha, Jang-Ho; Hannesdottir, Kristin (2022-08-10)
    BACKGROUND: More sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease (AD). Although conventional end points lack sensitivity, digital technologies hold ...
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    A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries 
    Chew, Michelle S.; Kattainen, Salla; Haase, Nicolai; Buanes, Eirik A.; Kristinsdóttir, Linda B.; Hofsø, Kristin; Laake, Jon Henrik; Kvåle, Reidar; Hästbacka, Johanna; Reinikainen, Matti; Bendel, Stepani; Varpula, Tero; Walther, Sten; Perner, Anders; Flaatten, Hans K.; Sigurðsson, Martin Ingi (2022-01)
    Background: We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, ...
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    Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia 
    Tigu, Adrian Bogdan; Constantinescu, Catalin Sorin; Teodorescu, Patric; Kegyes, David; Munteanu, Raluca; Feder, Richard; Peters, Mareike; Pralea, Ioana; Iuga, Cristina; Cenariu, Diana; Marcu, Andra; Tanase, Alina; Colita, Anca; Drula, Rares; Bergþórsson, Jón Þór; Greiff, Victor; Dima, Delia; Selicean, Cristina; Rus, Ioana; Zdrenghea, Mihnea; Gulei, Diana; Ghiaur, Gabriel; Tomuleasa, Ciprian (2023-10)
    Acute megakaryoblastic leukaemia (AMkL) is a rare subtype of acute myeloid leukaemia (AML) representing 5% of all reported cases, and frequently diagnosed in children with Down syndrome. Patients diagnosed with AMkL have low overall survival and have ...
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    Design centering of compact microwave components using response features and trust regions 
    Pietrenko-Dabrowska, Anna; Koziel, Slawomir (2021-12-18)
    Fabrication tolerances, as well as uncertainties of other kinds, e.g., concerning material parameters or operating conditions, are detrimental to the performance of microwave circuits. Mit-igating their impact requires accounting for possible parameter ...
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    Design specification management with automated decision-making for reliable optimization of miniaturized microwave components 
    Koziel, Slawomir; Pietrenko-Dabrowska, Anna; Plotka, Piotr (2022-01-17)
    The employment of numerical optimization techniques for parameter tuning of microwave components has nowadays become a commonplace. In pursuit of reliability, it is most often carried out at the level of full-wave electromagnetic (EM) simulation models, ...
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    Designing a Synthetic 3D-Printed Knee Cartilage: FEA Model, Micro-Structure and Mechanical Characteristics 
    Dolino, Gianmarco; Coato, Damiano; Forni, Riccardo; Boretti, Gabriele; Ciliberti, Federica Kiyomi; Gargiulo, Paolo (2024-01)
    Articular cartilage morphology and composition are essential factors in joint biomechanics, and their alteration is a crucial aspect of osteoarthritis (OA), a prevalent disease that causes pain and functional loss. This research focuses on developing ...
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    Detailed Multiplex Analysis of SARS-CoV-2 Specific Antibodies in COVID-19 Disease 
    Brynjólfsson, Siggeir Fannar; Sigurgrímsdóttir, Hildur; Einarsdóttir, Elín D.; Björnsdóttir, Guðrún Ása; Ármannsdóttir, Brynja; Baldvinsdóttir, Guðrún E.; Bjarnason, Agnar; Guðlaugsson, Ólafur; Guðmundsson, Sveinn Viðar; Sigurðardóttir, Sigurveig T.; Löve, Arthur; Kristinsson, Karl Gústaf; Lúðvíksson, Björn Rúnar (2021-06-10)
    A detailed understanding of the antibody response against SARS-CoV-2 is of high importance, especially with the emergence of novel vaccines. A multiplex-based assay, analyzing IgG, IgM, and IgA antibodies against the receptor binding domain (RBD), spike ...
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    Detection and Early Referral of Patients With Interstitial Lung Abnormalities : An Expert Survey Initiative 
    ILA Study Group (2022-02-01)
    Background: Interstitial lung abnormalities (ILA) may represent undiagnosed early-stage or subclinical interstitial lung disease (ILD). ILA are often observed incidentally in patients who subsequently develop clinically overt ILD. There is limited ...
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    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen 
    Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eiríkur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
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    Determinants of physical function in community dwelling old people 
    Geirsdottir, Olöf G.; Chang, Milan; Briem, Kristin; Jonsson, Pálmi V.; Thorsdottir, Inga; Ramel, Alfonso (2022-03)
    Background. Poor physical function is associated with disability and mortality in old people. Objectives. The aim was to find determinants of physical function in old people. Design. Secondary, cross-sectional analysis. Setting. Community in the ...
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    Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry : Proposal for a bone marrow quality index 
    Óskarsson, Jón Þórir; Rögnvaldsson, Sæmundur; Thorsteinsdottir, Sigrun; Aspelund, Thor; Gunnarsson, Steinar Bragi; Hákonardóttir, Guðlaug Katrín; Sigurðardóttir, Guðrún Ásta; Þórðardóttir, Ásdís Rósa; Gíslason, Gauti Kjartan; Ólafsson, Andri; Sigurðsson, Jón Kristinn; Eyþórsson, Elías; Jónsson, Ásbjörn; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni A.; Pálmason, Róbert; Sigurðardóttir, Margrét; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Harding, Stephen; Flores-Montero, Juan; Orfao, Alberto; Durie, Brian G.M.; Love, Thorvardur Jon; Kristinsson, Sigurdur Yngvi (2023-12-01)
    Hemodilution of bone marrow (BM) aspirates is a limitation of multiparameter flow cytometry (MFC) in plasma cell disorders. There is a need for a validated approach for assessing sample quality and the distribution of non-plasma cell BM populations by ...