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Using high density EEG to assess TMS treatment in patients with schizophrenia

Using high density EEG to assess TMS treatment in patients with schizophrenia

Title: Using high density EEG to assess TMS treatment in patients with schizophrenia
Author: Marcu, Sara
Pegolo, Elena
Ívarsson, Eysteinn
Jónasson, Aron Dalin   orcid.org/0000-0002-1414-0157
Jónasson, Viktor   orcid.org/0000-0002-5756-4865
Aubonnet, Romain   orcid.org/0000-0002-5395-775X
Gargiulo, Paolo   orcid.org/0000-0002-5049-4817
Banea, Ovidiu Constantin
Date: 2020-04-01
Language: English
Scope: 134-138
University/Institute: Háskólinn í Reykjavík
Reykjavik University
School: Tæknisvið (HR)
School of Technology (RU)
Department: Verkfræðideild (HR)
Department of Engineering (RU)
Series: European Journal of Translational Myology;30(1)
ISSN: 2037-7452
2037-7460 (eISSN)
DOI: doi.org/10.4081/ejtm.2019.8903
Subject: Transcranial magnetic stimulation; Schizophrenia; High density EEG; Electroencephalography; P50; P300; Geðklofi; Heilastarfsemi; Heilarit; Biomedical engineering
URI: https://hdl.handle.net/20.500.11815/2454

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Marcu, S., Pegolo, E., Ivarsson, E., Jonasson, A. D., Jonasson, V. D., Aubonnet, R., Gargiulo, P., & Banea, O. C. (2020). Using high density EEG to assess TMS treatment in patients with schizophrenia. European Journal of Translational Myology, 30(1), 134–138. https://doi.org/10.4081/ejtm.2019.8903


We present preliminary results from the ongoing study entitled "Icelandic AVH-TMS" which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory verbal hallucinations (AVH) using symptoms and psychometric scales and high-density EEG system (256 channels). The aim of the present work was to describe cortical topography of the auditory evoked responses like P50 and N100-P300 complex in healthy participants and patients with schizophrenia and to define a robust methodology of signal quantification using dense-array EEG. Preliminary data is shown for three healthy participants and three patients in baseline conditions and for two patients we show the results recorded before and after 10 days rTMS treatment. Our results show differences in sensory gating (P50 suppresion) and a stronger N100-P300 response to rare audio stimulus after the treatment. Moreover we show the value of assessing brain electrical activity from high-density EEG (256 channels) analyzing the results in different regions of interest. However, it is premature and hazardous to assume that rTMS treatment effectiveness in patients with AVH can be assessed using P50 suppression ratio.


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