dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Song, Huan |
dc.contributor.author |
Larsson, Henrik |
dc.contributor.author |
Fang, Fang |
dc.contributor.author |
Almqvist, Catarina |
dc.contributor.author |
Pedersen, Nancy L |
dc.contributor.author |
Magnusson, Patrik KE |
dc.contributor.author |
Valdimarsdottir, Unnur |
dc.date.accessioned |
2020-12-17T13:56:47Z |
dc.date.available |
2020-12-17T13:56:47Z |
dc.date.issued |
2020-07-14 |
dc.identifier.citation |
Song, H., Larsson, H., Fang, F., Almqvist, C., Pedersen, N.L., Magnusson, P.K., Valdimarsdóttir, U.A., 2020. Risk of psychiatric disorders among the surviving twins after a co-twin loss. eLife 9. doi:10.7554/elife.56860 |
dc.identifier.issn |
2050-084X |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2301 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a cotwin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age-and sex-matched non-bereaved twins. Compared to the non-bereaved twins, exposed twins were at increased risk of receiving a first diagnosis of psychiatric disorders (hazard ratio = 1.65, 95% confidence interval1.48–1.83), particularly during the first month after loss. Similarly, compared to non-twin full siblings, the relative risks were significantly increased after loss of monozygotic co-twin (2.45-fold), and loss of a dizygotic co-twin (1.29-fold), with higher HR observed with greater age gaps between twins and non-twin siblings. As dizygotic twins share equal genetic relatedness to the deceased twin as their full siblings, this pattern suggests that beyond the contribution of genetic factors, shared early life experiences and attachment contribute to the risk of psychiatric disorders among surviving twins after co-twin loss. |
dc.description.sponsorship |
The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council. |
dc.format.extent |
1-13 |
dc.language.iso |
en |
dc.publisher |
eLife Sciences Publications, Ltd |
dc.relation.ispartofseries |
eLife;9 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Twins |
dc.subject |
Psychiatric disorders |
dc.subject |
Tvíburar |
dc.subject |
Geðraskanir |
dc.subject |
Ástvinamissir |
dc.title |
Risk of psychiatric disorders among the surviving twins after a co-twin loss |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
eLife |
dc.identifier.doi |
10.7554/eLife.56860 |
dc.relation.url |
https://elifesciences.org/articles/56860 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |