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MITF and TFEB cross-regulation in melanoma cells

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Ballesteros Alvarez, Josue
dc.contributor.author Dilshat, Ramile
dc.contributor.author Fock, Valerie
dc.contributor.author Möller, Katrin
dc.contributor.author Karl, Ludwig
dc.contributor.author LARUE, Lionel
dc.contributor.author Ogmundsdottir, Margret H
dc.contributor.author Steingrimsson, Eirikur
dc.date.accessioned 2020-11-16T13:59:05Z
dc.date.available 2020-11-16T13:59:05Z
dc.date.issued 2020-09-03
dc.identifier.citation Citation: Ballesteros-Álvarez J, Dilshat R, Fock V, Möller K, Karl L, Larue L, et al. (2020) MITF and TFEB cross-regulation in melanoma cells. PLoS ONE 15(9): e0238546. https://doi.org/10.1371/journal.pone.0238546
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/2210
dc.description Publisher's version (útgefin grein)
dc.description.abstract The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in melanoma. The three related proteins MITF, TFEB and TFE3 have been shown to be involved in the biogenesis and function of lysosomes and autophagosomes, regulating cellular clearance pathways. Here we investigated the cross-regulatory relationship of MITF and TFEB in melanoma cells. Like MITF, the TFEB and TFE3 genes are expressed in melanoma cells as well as in melanoma tumors, albeit at lower levels. We show that the MITF and TFEB proteins, but not TFE3, directly affect each other’s mRNA and protein expression. In addition, the subcellular localization of MITF and TFEB is subject to regulation by the mTOR signaling pathway, which impacts their cross-regulatory relationship at the transcriptional level. Our work shows that the relationship between MITF and TFEB is multifaceted and that the cross-regulatory interactions of these factors need to be taken into account when considering pathways regulated by these proteins.
dc.description.sponsorship ES, 130230-052, Research fund of Iceland, www.rannis.is ES, 163413-051, Research fund of Iceland, www.rannis.is.
dc.format.extent e0238546
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries PLOS ONE;15(9)
dc.rights info:eu-repo/semantics/openAccess
dc.subject MITF
dc.subject TFEB
dc.subject Melanoma cells
dc.subject Erfðarannsóknir
dc.subject Genarannsóknir
dc.title MITF and TFEB cross-regulation in melanoma cells
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0238546
dc.relation.url https://dx.plos.org/10.1371/journal.pone.0238546
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Lífvísindasetur (HÍ)
dc.contributor.department Biomedical Center (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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