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Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials

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dc.contributor Háskólinn í Reykjavík
dc.contributor Reykjavik University
dc.contributor.author Kronish, Ian M.
dc.contributor.author Cheung, Ying Kuen
dc.contributor.author Julian, Jacob
dc.contributor.author Parsons, Faith
dc.contributor.author Lee, Jenny
dc.contributor.author Yoon, Sunmoo
dc.contributor.author Valdimarsdottir, Heiddis
dc.contributor.author Green, Paige
dc.contributor.author Suls, Jerry
dc.contributor.author Hershman, Dawn L.
dc.contributor.author Davidson, Karina W.
dc.date.accessioned 2020-11-03T15:46:36Z
dc.date.available 2020-11-03T15:46:36Z
dc.date.issued 2019-12-30
dc.identifier.citation Kronish, I. M., Cheung, Y. K., Julian, J., Parsons, F., Lee, J., Yoon, S., Valdimarsdottir, H., Green, P., Suls, J., Hershman, D. L., & Davidson, K. W. (2020). Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials. HEALTHCARE, 8(1). https://doi.org/10.3390/healthcare8010010
dc.identifier.issn 2227-9032 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/2160
dc.description Publisher's version (útgefin grein)
dc.description.abstract Purpose: Little is known about the effectiveness of bright white light therapy (BWL) for depressive symptoms in cancer survivors, many of whom prefer non-pharmacological treatments. The purpose of this study was to compare the effectiveness of BWL versus dim red light therapy (DRL) on depressive symptoms within individual cancer survivors using personalized (N-of-1) trials. Methods: Cancer survivors with at least mild depressive symptoms were randomized to one of two treatment sequences consisting of counterbalanced crossover comparisons of three-weeks of lightbox-delivered BWL (intervention) or DRL (sham) for 30 min each morning across 12 weeks. A smartphone application guided cancer survivors through the treatment sequence and facilitated data collection. Cancer survivors tracked end-of-day depressive symptoms (primary outcome) and fatigue using visual analog scales. Within-patient effects of BWL were assessed using an autoregressive model with adjustment for linear time trends. Results: Eight of nine cancer survivors completed the 12-week protocol. Two survivors reported significantly (i.e., p < 0.05) lower depressive symptoms (-1.3 +/- 0.5 and -1.30 +/- 0.9 points on a 10-point scale), five reported no difference in depressive symptoms, and one reported higher depressive symptoms (+1.7 +/- 0.6 points) with BWL versus DRL. Eight of nine cancer survivors recommended personalized trials of BWL to others. Conclusions: There were heterogeneous effects of three-week BWL on self-reported depressive symptoms among cancer survivors, with some finding a benefit but others finding no benefit or even harm. Implications for Cancer Survivors: Personalized trials can help cancer survivors learn if BWL is helpful for improving their depressive symptoms.
dc.description.sponsorship This research was funded in part with Federal funds from the National Cancer Institute, NIH, under Contract No. HHSN261200800001E. Drs. Kronish, Davidson, and Cheung received additional support from the National Library of Medicine (R01LM012836).
dc.format.extent 10
dc.language.iso en
dc.publisher MDPI AG
dc.relation.ispartofseries Healthcare;8(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Depression
dc.subject Cancer survivors
dc.subject Bright white light therapy
dc.subject N-of-1 trials
dc.subject Personalized medicine
dc.subject Þunglyndi
dc.subject Ljósameðferð
dc.subject Krabbameinssjúklingar
dc.title Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials
dc.type info:eu-repo/semantics/article
dcterms.license This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.description.version "Peer Reviewed"
dc.identifier.doi 10.3390/healthcare8010010
dc.relation.url https://www.mdpi.com/2227-9032/8/1/10/pdf
dc.contributor.department Sálfræðideild (HR)
dc.contributor.department Department of Psychology (RU)
dc.contributor.school Samfélagssvið (HR)
dc.contributor.school School of Social Sciences (RU)

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