dc.contributor |
Háskólinn í Reykjavík |
dc.contributor |
Reykjavik University |
dc.contributor.author |
Kronish, Ian M. |
dc.contributor.author |
Cheung, Ying Kuen |
dc.contributor.author |
Julian, Jacob |
dc.contributor.author |
Parsons, Faith |
dc.contributor.author |
Lee, Jenny |
dc.contributor.author |
Yoon, Sunmoo |
dc.contributor.author |
Valdimarsdottir, Heiddis |
dc.contributor.author |
Green, Paige |
dc.contributor.author |
Suls, Jerry |
dc.contributor.author |
Hershman, Dawn L. |
dc.contributor.author |
Davidson, Karina W. |
dc.date.accessioned |
2020-11-03T15:46:36Z |
dc.date.available |
2020-11-03T15:46:36Z |
dc.date.issued |
2019-12-30 |
dc.identifier.citation |
Kronish, I. M., Cheung, Y. K., Julian, J., Parsons, F., Lee, J., Yoon, S., Valdimarsdottir, H., Green, P., Suls, J., Hershman, D. L., & Davidson, K. W. (2020). Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials. HEALTHCARE, 8(1). https://doi.org/10.3390/healthcare8010010 |
dc.identifier.issn |
2227-9032 (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2160 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Purpose: Little is known about the effectiveness of bright white light therapy (BWL) for depressive symptoms in cancer survivors, many of whom prefer non-pharmacological treatments. The purpose of this study was to compare the effectiveness of BWL versus dim red light therapy (DRL) on depressive symptoms within individual cancer survivors using personalized (N-of-1) trials. Methods: Cancer survivors with at least mild depressive symptoms were randomized to one of two treatment sequences consisting of counterbalanced crossover comparisons of three-weeks of lightbox-delivered BWL (intervention) or DRL (sham) for 30 min each morning across 12 weeks. A smartphone application guided cancer survivors through the treatment sequence and facilitated data collection. Cancer survivors tracked end-of-day depressive symptoms (primary outcome) and fatigue using visual analog scales. Within-patient effects of BWL were assessed using an autoregressive model with adjustment for linear time trends. Results: Eight of nine cancer survivors completed the 12-week protocol. Two survivors reported significantly (i.e., p < 0.05) lower depressive symptoms (-1.3 +/- 0.5 and -1.30 +/- 0.9 points on a 10-point scale), five reported no difference in depressive symptoms, and one reported higher depressive symptoms (+1.7 +/- 0.6 points) with BWL versus DRL. Eight of nine cancer survivors recommended personalized trials of BWL to others. Conclusions: There were heterogeneous effects of three-week BWL on self-reported depressive symptoms among cancer survivors, with some finding a benefit but others finding no benefit or even harm. Implications for Cancer Survivors: Personalized trials can help cancer survivors learn if BWL is helpful for improving their depressive symptoms. |
dc.description.sponsorship |
This research was funded in part with Federal funds from the National Cancer Institute, NIH, under Contract No. HHSN261200800001E. Drs. Kronish, Davidson, and Cheung received additional support from the National Library of Medicine (R01LM012836). |
dc.format.extent |
10 |
dc.language.iso |
en |
dc.publisher |
MDPI AG |
dc.relation.ispartofseries |
Healthcare;8(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Depression |
dc.subject |
Cancer survivors |
dc.subject |
Bright white light therapy |
dc.subject |
N-of-1 trials |
dc.subject |
Personalized medicine |
dc.subject |
Þunglyndi |
dc.subject |
Ljósameðferð |
dc.subject |
Krabbameinssjúklingar |
dc.title |
Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.description.version |
"Peer Reviewed" |
dc.identifier.doi |
10.3390/healthcare8010010 |
dc.relation.url |
https://www.mdpi.com/2227-9032/8/1/10/pdf |
dc.contributor.department |
Sálfræðideild (HR) |
dc.contributor.department |
Department of Psychology (RU) |
dc.contributor.school |
Samfélagssvið (HR) |
dc.contributor.school |
School of Social Sciences (RU) |