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Nitroxide‐Derived N‐Oxide Phenazines for Noncovalent Spin‐Labeling of DNA

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Juliusson, Haraldur Y.
dc.contributor.author Sigurdsson, Snorri
dc.date.accessioned 2020-08-11T15:40:12Z
dc.date.available 2020-08-11T15:40:12Z
dc.date.issued 2020-07
dc.identifier.citation Juliusson, H. Y., & Sigurdsson, S. T. (2020). Nitroxide-derived N-oxide phenazines for noncovalent spin-labeling of DNA. ChemBioChem, doi: 10.1002/cbic.202000128
dc.identifier.issn 1439-4227
dc.identifier.issn 1439-7633 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/1975
dc.description Post-print (lokagerð höfundar)
dc.description.abstract Two o‐benzoquinone derivatives of isoindoline were synthesized for use as building blocks to incorporate isoindoline nitroxides into different compounds and materials. These o‐quinones were condensed with a number of o‐phenylenediamines to form isoindoline‐phenazines in high yields. Subsequent oxidation gave phenazine‐di‐N‐oxide isoindoline nitroxides that were evaluated for noncovalent and site‐directed spin‐labeling of duplex DNA and RNA that contained abasic sites. Although only minor binding was observed for RNA, the unsubstituted phenazine‐N,N‐dioxide tetramethyl isoindoline nitroxide showed high binding affinity and selectivity towards abasic sites in duplex DNA that contained cytosine as the orphan base.
dc.description.sponsorship The authors acknowledge financial support from the Icelandic Research Fund (173727-051). The authors thank Dr S. Jonsdottir for assistance with collecting analytical data for structural characterization of new compounds, Dr. Thomas Halbritter for critically reading this manuscript, and the members of the Sigurdsson research group for helpful discussions.
dc.language.iso en
dc.publisher Wiley
dc.rights info:eu-repo/semantics/embargoedAccess
dc.subject Aminoxyl radicals
dc.subject EPR spectroscopy
dc.subject Noncovalent spin labels
dc.subject Oligonucleotides
dc.subject Phenazines
dc.subject Litrófsgreining
dc.subject Sameindaerfðafræði
dc.title Nitroxide‐Derived N‐Oxide Phenazines for Noncovalent Spin‐Labeling of DNA
dc.type info:eu-repo/semantics/article
dcterms.license This is the peer reviewed version of the following article: [Juliusson, H. Y., & Sigurdsson, S. T. (2020). Nitroxide-derived N-oxide phenazines for noncovalent spin-labeling of DNA. ChemBioChem, doi: 10.1002/cbic.202000128], which has been published in final form at https://doi.org/10.1002/cbic.202000128. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.description.version Peer reviewed
dc.identifier.journal ChemBioChem
dc.identifier.doi 10.1002/cbic.202000128
dc.contributor.department Raunvísindadeild (HÍ)
dc.contributor.department Faculty of Physical Sciences (UI)
dc.contributor.department Raunvísindastofnun (HÍ)
dc.contributor.department Science Institute (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)
dc.contributor.school School of Engineering and Natural Sciences (UI)

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