Opin vísindi

Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current

Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current


Title: Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current
Author: Hugosdottir, Rosa
Mørch, Carsten Dahl
Andersen, Ole Kæseler
Helgason, Thordur
Arendt-Nielsen, Lars
Date: 2019-09-14
Language: English
Scope: 48
University/Institute: Háskólinn í Reykjavík
Reykjavik University
School: Tæknisvið (HR)
School of Technology (RU)
Department: Verkfræðideild (HR)
Department of Engineering (RU)
Series: BMC Neuroscience;20(1)
ISSN: 1471-2202
DOI: 10.1186/s12868-019-0530-8
Subject: General Neuroscience; Cellular and Molecular Neuroscience; Electrical stimulation; Electrical pulse shapes; Pin electrode; Patch electrode; Small fiber activation; Large fiber accommodation; Nerve Fibers; Pain perception; Stimulation; Perception; Taugavísindi; Raförvun; Taugaboð; Leiðarar (rafmagn); Áreiti; Trefjar; Taugavefur; Skynjun; Sársaukaskyn; Verkjameðferð
URI: https://hdl.handle.net/20.500.11815/1877

Show full item record

Citation:

Hugosdottir, R., Morch, C. D., Andersen, O. K., Helgason, T., & Arendt-Nielsen, L. (2019). Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current. Bmc Neuroscience, 20(1), 48. https://doi.org/10.1186/s12868-019-0530-8

Abstract:

Background Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers are activated at a lower threshold than small fibers. Pin electrodes have been designed for overcoming this problem by providing a higher current density in the upper epidermis where the small nociceptive fibers mainly terminate. At perception threshold level, pin electrode stimuli are rather selectively activating small nerve fibers and are perceived as painful, but for high current intensity, which is usually needed to evoke sufficient pain levels, large fibers are likely co-activated. Long duration current has been shown to elevate the threshold of large fibers by the mechanism of accommodation. However, it remains unclear whether the mechanism of accommodation in large fibers can be utilized to activate small fibers even more selectively by combining pin electrode stimulation with a long duration pulse. Results In this study, perception thresholds were determined for a patch- and a pin electrode for different pulse shapes of long duration. The perception threshold ratio between the two different electrodes was calculated to estimate the ability of the pulse shapes to preferentially activate small fibers. The perception threshold ratios were compared between stimulation pulses of 5- and 50 ms durations and shapes of: exponential increase, linear increase, bounded exponential, and rectangular. Qualitative pain perception was evaluated for all pulse shapes delivered at 10 times perception threshold. The results showed a higher perception threshold ratio for long duration 50 ms pulses than for 5 ms pulses. The highest perception threshold ratio was found for the 50 ms, bounded exponential pulse shape. Results furthermore revealed different strength-duration relation between the bounded exponential- and rectangular pulse shapes. Pin electrode stimulation at high intensity was mainly described as "stabbing", "shooting", and "sharp". Conclusion These results indicate that long duration pulses with a bounded exponential increase preferentially activate the small nociceptive fibers with a pin electrode and concurrently cause elevated threshold of large non-nociceptive fibers with patch electrodes.

Description:

Publisher's version (útgefin grein)

Rights:

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

Files in this item

This item appears in the following Collection(s)