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Outbreak of viral haemorrhagic septicaemia (VHS) in lumpfish (Cyclopterus lumpus) in Iceland caused by VHS virus genotype IV

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Guðmundsdóttir, Sigríður
dc.contributor.author Vendramin, Niccoló
dc.contributor.author Cuenca, Argelia
dc.contributor.author Sigurðardóttir, Heiða
dc.contributor.author Kristmundsson, Árni
dc.contributor.author Iburg, Tine Moesgaard
dc.contributor.author Olesen, Niels Jørgen
dc.date.accessioned 2019-11-14T13:52:45Z
dc.date.available 2019-11-14T13:52:45Z
dc.date.issued 2018-11-05
dc.identifier.citation Guðmundsdóttir, S, Vendramin, N, Cuenca, A, et al. Outbreak of viral haemorrhagic septicaemia (VHS) in lumpfish (Cyclopterus lumpus) in Iceland caused by VHS virus genotype IV. J Fish Dis. 2019; 42: 47– 62. https://doi.org/10.1111/jfd.12910
dc.identifier.issn 0140-7775
dc.identifier.issn 1365-2761 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/1336
dc.description Publisher's version (útgefin grein)
dc.description.abstract A novel viral haemorrhagic septicaemia virus (VHSV) of genotype IV was isolated from wild lumpfish (Cyclopterus lumpus), brought to a land-based farm in Iceland, to serve as broodfish. Two groups of lumpfish juveniles, kept in tanks in the same facility, got infected. The virus isolated was identified as VHSV by ELISA and real-time RT-PCR. Phylogenetic analysis, based on the glycoprotein (G) gene sequences, may indicate a novel subgroup of VHSV genotype IV. In controlled laboratory exposure studies with this new isolate, there was 3% survival in the I.P. injection challenged group while there was 90% survival in the immersion group. VHSV was not re-isolated from fish challenged by immersion. In a cohabitation trial, lumpfish infected I.P. (shedders) were placed in tanks with naïve lumpfish as well as naïve Atlantic salmon (Salmo salar L.). 10% of the lumpfish shedders and 43%–50% of the cohabiting lumpfish survived after 4 weeks. 80%–92% of the Atlantic salmon survived, but no viral RNA was detected by real-time RT-PCR nor VHSV was isolated from Atlantic salmon. This is the first isolation of a notifiable virus in Iceland and the first report of VHSV of genotype IV in European waters.
dc.description.sponsorship H2020 SFS-2014-2 ParaFishControl, Grant/ Award Number: 634429; European Union Reference Laboratory for Fish Diseases Grant Decision SI2.725290
dc.format.extent 47-62
dc.language.iso en
dc.publisher Wiley
dc.relation info:eu-repo/grantAgreement/EC/H2020/634429
dc.relation.ispartofseries Journal of Fish Diseases;42(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Challenge models
dc.subject Genotype IV
dc.subject Iceland
dc.subject Lumpfish
dc.subject Viral haemorrhagic septicaemia virus (VHSV)
dc.subject Hrognkelsi
dc.subject Veirur
dc.title Outbreak of viral haemorrhagic septicaemia (VHS) in lumpfish (Cyclopterus lumpus) in Iceland caused by VHS virus genotype IV
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.description.version Peer Reviewed
dc.identifier.journal Journal of Fish Diseases
dc.identifier.doi 10.1111/jfd.12910
dc.contributor.department Tilraunastöð í meinafræði að Keldum (HÍ)
dc.contributor.department Institute for Experimental Pathology, Keldur (UI)

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